ArticleAmerican journal of nuclear medicine and molecular imaging2011
Imaging of Induced Pluripotent Stem Cells: From Cellular Reprogramming to Transplantation.
Article in American journal of nuclear medicine and molecular imaging, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed.
- HoApplied biochemistry and biotechnology · 2023Article
- A Concise Review on Induced Pluripotent Stem Cell-Derived Cardiomyocytes for Personalized Regenerative Medicine.Stem cell reviews and reports · 2021Review
- A Review on Green Synthesis, Biomedical Applications, and Toxicity Studies of ZnO NPs.Bioinorganic chemistry and applications · 2018Review
- Inhibition of DNA topoisomerase II selectively reduces the threat of tumorigenicity following induced pluripotent stem cell-based myocardial therapy.Stem cells and development · 2014Article
- Induced pluripotent stem cells for post-myocardial infarction repair: remarkable opportunities and challenges.Circulation research · 2014Review
- Preclinical studies for induced pluripotent stem cell-based therapeutics.The Journal of biological chemistry · 2014Review
- Biomedical applications of zinc oxide nanomaterials.Current molecular medicine · 2013Review
- Functionalized upconversion nanoparticles: versatile nanoplatforms for translational research.Current molecular medicine · 2013Review
- Antibody-based imaging of HER-2: moving into the clinic.Current molecular medicine · 2013Review
- Quantum dot-based nanoprobes for in vivo targeted imaging.Current molecular medicine · 2013Review
- Multimodality imaging of CXCR4 in cancer: current status towards clinical translation.Current molecular medicine · 2013Review
- Positron emission tomography imaging of atherosclerosis.Theranostics · 2013Review
- Positron emission tomography based in-vivo imaging of early phase stem cell retention after intramyocardial delivery in the mouse model.European journal of nuclear medicine and molecular imaging · 2013Article
- Noninvasive detection of human-induced pluripotent stem cell (hiPSC)-derived teratoma with an integrin-targeting agent (99m)Tc-3PRGD2.Molecular imaging and biology · 2013Article
- Multimodality imaging of RNA interference.Current medicinal chemistry · 2013Review
- Molecular imaging strategies for in vivo tracking of microRNAs: a comprehensive review.Current medicinal chemistry · 2013Review
- HaloTag as a reporter gene: positron emission tomography imaging with (64)Cu-labeled second generation HaloTag ligands.American journal of translational research · 2013Article
- Graphene: a versatile nanoplatform for biomedical applications.Nanoscale · 2012Review
- Specimen collection for induced pluripotent stem cell research: harmonizing the approach to informed consent.Stem cells translational medicine · 2012Article
- Molecular imaging of insulin-like growth factor 1 receptor in cancer.American journal of nuclear medicine and molecular imaging · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Successful reprogramming of somatic cells into induced pluripotent stem cells (iPSCs) ushered in a new era of regenerative medicine. Human iPSCs provide powerful new approaches for disease modeling, drug testing, developmental studies, and therapeutic applications. Investigating iPSC behavior in vivo and the ultimate feasibility of cell transplantation therapy necessitates the development of novel imaging techniques to longitudinally monitor iPSC localization, proliferation, integration, and differentiation in living subjects. At this five year mark of initial iPSC discovery, we review the current status of imaging iPSCs which ranges from in vitro studies, where imaging was used to study the processes/mechanisms of cellular reprogramming, to in vivo imaging of the survival of transplanted cells. To date, most imaging studies of iPSCs have been based on optical techniques, which include fluorescence and bioluminescence imaging. Since each imaging technique has its advantages and limitations, a combination of multiple imaging modalities may provide complementary information. The ideal imaging approach for tracking iPSCs or their derivatives in patients requires the imaging tag to be non-toxic, biocompatible, and highly specific to reduce perturbation of these cells. In few other scenarios can "personalized medicine" be better illustrated than the use of individual patient-specific iPSCs. Much future effort will be required before this can become a reality and clinical routine, where imaging will play an indispensible role in many facets of iPSC-based research and therapies.
Identifiers
21841970PMC3155258What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.