Evidence map›Paper›PMID 21841793›Full record

ArticleNature cell biology2011

Notch post-translationally regulates β-catenin protein in stem and progenitor cells.

Chulan Kwon, Paul Cheng, Isabelle N King, Peter Andersen, Lincoln Shenje, Vishal Nigam, Deepak Srivastava

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature cell biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 167 papers.

0numbers the graph read from it
0cells of the map it votes in
167citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

167 citing papers in PubMed.

  1. Review
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  6. Role of Notch signaling pathway in joint homeostasis and osteoarthritis.Frontiers in bioengineering and biotechnology · 2026
    Review
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  8. Article
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  15. Article
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107 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Chulan KwonGladstone Institute of Cardiovascular Disease and Department of Pediatrics, University of California, San Francisco, 1650 Owens Street, San Francisco, California 94158, USA. ckwon13@jhmi.edu
Paul Cheng
Isabelle N King
Peter Andersen
Lincoln Shenje
Vishal Nigam
Deepak Srivastava

Funding

Transcriptional Networks During Cardiac DifferentiationP01HL089707 · NHLBI · J. DAVID GLADSTONE INSTITUTES · PI SRIVASTAVA, DEEPAK · 2008 to 2017
$20.4M
Induced Pluripotent Stem Cells in the Understanding and Treatment of Heart DiseasU01HL100406 · NHLBI · J. DAVID GLADSTONE INSTITUTES · PI BRUNEAU, BENOIT GAETAN, CONKLIN, BRUCE R · 2009 to 2015
$9.4M
EXTRAMULAR RESEARCH FACILITIES CONSTRUCTIONC06RR018928 · NCRR · J. DAVID GLADSTONE INSTITUTES · PI MAHLEY, ROBERT W. · 2003 to 2003
$2.1M
Isl1 and Wntbeta-catenin regulation of cardiac progenitor cellsR00HL092234 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI KWON, CHULAN · 2011 to 2013
$730k
Hairy-Related Factors in Cardiac Development and DiseaseK08HL079260 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KING, ISABELLE N · 2005 to 2009
$523k
Isl1 and Wntbeta-catenin regulation of cardiac progenitor cellsK99HL092234 · NHLBI · J. DAVID GLADSTONE INSTITUTES · PI KWON, CHULAN · 2009 to 2010
$206k
NCRR NIH HHS C06 RR018928NHLBI NIH HHS 1K99HL092234NHLBI NIH HHS 4R00HL09223NHLBI NIH HHS K08 HL079260NHLBI NIH HHS K99 HL092234NHLBI NIH HHS P01 HL089707NHLBI NIH HHS R00 HL092234NHLBI NIH HHS U01 HL100406
6 · The paper itself

Abstract

Cellular decisions of self-renewal or differentiation arise from integration and reciprocal titration of numerous regulatory networks. Notch and Wnt/β-catenin signalling often intersect in stem and progenitor cells and regulate each other transcriptionally. The biological outcome of signalling through each pathway often depends on the context and timing as cells progress through stages of differentiation. Here, we show that membrane-bound Notch physically associates with unphosphorylated (active) β-catenin in stem and colon cancer cells and negatively regulates post-translational accumulation of active β-catenin protein. Notch-dependent regulation of β-catenin protein did not require ligand-dependent membrane cleavage of Notch or the glycogen synthase kinase-3β-dependent activity of the β-catenin destruction complex. It did, however, require the endocytic adaptor protein Numb and lysosomal activity. This study reveals a previously unrecognized function of Notch in negatively titrating active β-catenin protein levels in stem and progenitor cells.

Indexed as

Protein Processing, Post-TranslationalAnimalsbeta CateninCell DifferentiationCell ProliferationColonic NeoplasmsEmbryonic Stem CellsGlycogen Synthase Kinase 3Glycogen Synthase Kinase 3 betaHT29 CellsHumansImmunoglobulin J Recombination Signal Sequence-Binding ProteinMembrane ProteinsMiceMice, KnockoutNerve Tissue Proteinsbeta CateninCTNNB1 protein, humanCTNNB1 protein, mouseGlycogen Synthase Kinase 3Glycogen Synthase Kinase 3 betaGSK3B protein, humanGsk3b protein, mouseImmunoglobulin J Recombination Signal Sequence-Binding ProteinMembrane ProteinsNerve Tissue ProteinsNOTCH1 protein, humanNotch1 protein, mouseNUMB protein, humanNumb protein, mouseRbpj protein, mouseReceptor, Notch1

Identifiers

PMID21841793
PMCPMC3187850

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.