Evidence map›Paper›PMID 21841478›Full record

ReviewCurrent opinion in anaesthesiology2011

The pathophysiology of acute pain: animal models.

Jun Xu, Timothy J Brennan

Abstract readReview
In one paragraph

Review in Current opinion in anaesthesiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Article
  2. The anti-nociceptive effect of BPC-157 on the incisional pain model in rats.Journal of dental anesthesia and pain medicine · 2022
    Article
  3. Article
  4. Article
  5. Accelerated Solvent Extractions (ASE) ofMolecules (Basel, Switzerland) · 2021
    Article
  6. Investigating the Role of Ly6GFrontiers in pain research (Lausanne, Switzerland) · 2021
    Article
  7. The Hydroethanolic Stem Bark Extract ofEvidence-based complementary and alternative medicine : eCAM · 2021
    Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Pain after knee arthroplasty: an unresolved issue.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2014
    Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Jun XuNeuroscience Research, Abbott Laboratories, Abbott Park, Illinois, USA.
Timothy J Brennan

Funding

Primary Afferent Sensitization in Postoperative PainR01GM067762 · NIGMS · UNIVERSITY OF IOWA · PI BRENNAN, TIMOTHY JOHN · 2003 to 2012
$2.5M
TRPV1 Expressing Sensory Afferents in Postoperative PainR01GM055831 · NIGMS · UNIVERSITY OF IOWA · PI BRENNAN, TIMOTHY JOHN · 2002 to 2009
$2.4M
MECHANISMS OF POSTOPERATIVE PAINR29GM055831 · NIGMS · UNIVERSITY OF IOWA · PI BRENNAN, TIMOTHY JOHN · 1997 to 2001
$186k
NIGMS NIH HHS GM-55831NIGMS NIH HHS R01 GM055831NIGMS NIH HHS R01 GM067762NIGMS NIH HHS R29 GM055831
6 · The paper itself

Abstract

purpose of reviewTrauma, surgery, and burns are three common clinical scenarios that are associated with significant acute pain. This review describes the pathophysiology of acute pain utilizing three preclinical models: surgery, burn, and fracture. RECENT

findingsIn general, there is greater interest directed toward peripheral mediators of acute pain. Studies indicate that treatment against nerve growth factor, interleukins, and ischemic-like mediators may provide valuable avenues for treatment of acute pain. By targeting the periphery, analgesic therapies may have reduced side-effects. SUMMARY: Peripheral mediators of acute pain can vary depending upon the type of injury. Treatment aimed toward those mediators specific to the injury may improve acute pain management in the future. It will be important to translate these findings into clinical trials in the future.

Indexed as

Acute PainAnalgesicsAnimalsBurnsDisease Models, AnimalFractures, BoneHumansPostoperative PainAnalgesics

Identifiers

PMID21841478
PMCPMC3259564

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.