ArticleJournal of immunology (Baltimore, Md. : 1950)2011
Cytoplasmic Ig alpha serine/threonines fine-tune Ig alpha tyrosine phosphorylation and limit bone marrow plasma cell formation.
Article in Journal of immunology (Baltimore, Md. : 1950), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed, 10 citations in OpenAlex.
- Scoring gene importance by interpreting single-cell foundation models.Nature biotechnology · 2026Article
- Role of inhibitory signaling in peripheral B cell tolerance.Immunological reviews · 2022Review
- Profiling the Atlantic Salmon IgMFrontiers in immunology · 2019Article
- γδ T cells affect IL-4 production and B-cell tolerance.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Expression of the B-cell receptor component CD79a on immature myeloid cells contributes to their tumor promoting effects.PloS one · 2013Article
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Authors and funding
9 authors at 6 institutions in 1 country.
Funding
Abstract
Igα serine 191 and 197 and threonine 203, which are located in proximity of the Igα ITAM, dampen Igα ITAM tyrosine phosphorylation. In this study, we show that mice with targeted mutations of Igα S191, 197, and T203 displayed elevated serum IgG2c and IgG2b concentrations and had elevated numbers of IgG2c- and IgG2b-secreting cells in the bone marrow. BCR-induced Igα tyrosine phosphorylation was slightly increased in splenic B cells. Our results suggest that Igα serine/threonines limit formation of IgG2c- and IgG2b-secreting bone marrow plasma cells, possibly by fine-tuning Igα tyrosine-mediated BCR signaling.
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Registered trials
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