ReviewPhysiology (Bethesda, Md.)2011
Itch signaling in the nervous system.
Review in Physiology (Bethesda, Md.), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
43 citing papers in PubMed, 3 syntheses or guidelines pooled it, 101 citations in OpenAlex.
- Interventions for postburn pruritus.The Cochrane database of systematic reviews · 2024Pooled it
- IL-31 Inhibition as a Therapeutic Approach for the Management of Chronic Pruritic Dermatoses.Drugs · 2021Pooled it
- Pain care for patients with epidermolysis bullosa: best care practice guidelines.BMC medicine · 2014Guideline
- Tmem45b modulates itch via endoplasmic reticulum calcium regulation.Frontiers in physiology · 2025Article
- Site-Specific Transient Receptor Potential Channel Mechanisms and Their Characteristics for Targeted Chronic Itch Treatment.Biomolecules · 2024Review
- Emerging concepts in neuropathic and neurogenic itch.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2023Review
- Brain Oscillatory Activity during Tactile Stimulation Correlates with Cortical Thickness of Intact Areas and Predicts Outcome in Post-Traumatic Comatose Patients.Brain sciences · 2020Article
- Post-Burn Pruritus.International journal of molecular sciences · 2020Review
- Exploration of sensory and spinal neurons expressing gastrin-releasing peptide in itch and pain related behaviors.Nature communications · 2020Article
- IL-6/p-BTK/p-ERK signaling mediates calcium phosphate-induced pruritus.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- The Itch-Scratch Cycle: A Neuroimmune Perspective.Trends in immunology · 2018Review
- Antipruritic effect of curcumin on histamine-induced itching in mice.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2018Article
- Cooling Relief of Acute and Chronic Itch Requires TRPM8 Channels and Neurons.The Journal of investigative dermatology · 2018Article
- Spinal Mechanisms of Itch Transmission.Neuroscience bulletin · 2018Review
- Article
- Pruritus: Progress toward Pathogenesis and Treatment.BioMed research international · 2018Review
- Making sense out of spinal cord somatosensory development.Development (Cambridge, England) · 2016Review
- Trp channels and itch.Seminars in immunopathology · 2016Review
- Article
- Anogenital Pruritus - An Overview.Journal of clinical and diagnostic research : JCDR · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Itch is a major somatic sensation, along with pain, temperature, and touch, detected and relayed by the somatosensory system. Itch can be an acute sensation, associated with mosquito bite, or a chronic condition, like atopic dermatitis (29, 59). The origins of the stimulus can be localized in the periphery or systemic, and associated with organ failure or cancer. Itch is also a perception originating in the brain. Itch is broadly characterized as either histamine-dependent (histaminergic) or histamine-independent (nonhistaminergic), both of which are relayed by subsets of C fibers and by the second-order neurons expressing gastrin-releasing peptide receptor (GRPR) and spinothalamic track (STT) neurons in the spinal cord of rodents. Historically, itch research has been primarily limited to clinical and psychophysical studies and to histamine-mediated mechanisms. In contrast, little is known about the signaling mechanisms underlying nonhistaminergic itch, despite the fact that the majority of chronic itch are mediated by nonhistaminergic mechanisms. During the past few years, important progress has been made in understanding the molecular signaling of itch, largely due to the introduction of mouse genetics. In this review, we examine some of the molecular mechanisms underlying itch sensation with an emphasis on recent studies in rodents.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.