ReviewAmerican journal of physiology. Heart and circulatory physiology2011
Cardiovascular regulation by skeletal muscle reflexes in health and disease.
Review in American journal of physiology. Heart and circulatory physiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04013022 (The Effects of Lifelong Endurance and Strength Training on the Central and Peripheral Cardiovascular Responses), which is not on this map. Cited by 80 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effects of Lifelong Endurance and Strength Training on the Central and Peripheral Cardiovascular Responses
Who cites it
80 citing papers in PubMed, 162 citations in OpenAlex.
- Innovative Dose-Response Assessment of the Metaboreflex With Indirect Control of Intramuscular Metabolic Perturbation in Humans.Acta physiologica (Oxford, England) · 2026Trial
- Short-term creatine supplementation enhances strength, reduces fatigue, and accelerates recovery in resistance-trained athletes: a double-blind, randomized, crossover trial.Journal of the International Society of Sports Nutrition · 2025Trial
- Heart rate variability response of intensity-matched strength training dependent on body position in females: a pilot randomized crossover study : Autonomic responses of strength training depending on body position.Scientific reports · 2025Trial
- Orthostatic-dependent cardiopulmonary responses among trained females during intensity matched resistance exercises in a pilot randomized crossover study.Scientific reports · 2025Trial
- Altered Skeletal Muscle Phosphate Metabolism After Muscle Damage Is Associated With Elevated Effort Perception During Exercise in Humans.Scandinavian journal of medicine & science in sports · 2026Article
- Prognostic value of exercise blood pressure: role of fitness and exercise training.American journal of physiology. Heart and circulatory physiology · 2026Review
- A secondary analysis of autonomic function during high-intensity interval exercise in adults with chronic stroke.Physiological reports · 2026Article
- Cardiovascular responses during blood flow-restricted resistance exercise: a systematic review with meta-analysis.BMJ open sport & exercise medicine · 2026Article
- The effects of exercise training on cardiovascular responses to muscle metaboreflex activation in patients after coronary artery bypass grafting.European journal of applied physiology · 2025Article
- Stretch-induced blood pressure moderation: A potential basis for the sense of well-being accompanying stretching of upper back and neck muscles.Physiological reports · 2025Article
- Validation of a novel multi-exercise approach to isometric resistance training in normotensive adults.European journal of applied physiology · 2025Article
- High Dietary Phosphate Intake Induces Hypertension and Sympathetic Overactivation via Central Fibroblast Growth Factor Receptor Signaling.Circulation · 2025Article
- Commentary: are postconcussive symptoms and exercise testing appropriate tools to identify autonomic impairment after mild traumatic brain injury?The Clinical neuropsychologist · 2025Review
- Article
- Muscle energetics and the cardiovascular response to isometric exercise and post-exercise circulatory occlusion following exercise-induced muscle damage: insights from multiparametric MRI.Frontiers in physiology · 2025Article
- Influence of blood lactate variations and passive exercise on cardiac responses.Journal of physical therapy science · 2024Article
- Evidence of spontaneous cardiac-locomotor coupling during daily activities in healthy adults.Frontiers in physiology · 2024Article
- Effects of exercise induced muscle damage on cardiovascular responses to isometric muscle contractions and post-exercise circulatory occlusion.European journal of applied physiology · 2023Article
- Low-load blood flow restriction reduces time-to-minimum single motor unit discharge rate.Experimental brain research · 2023Article
- Neurocirculatory regulation and adaptations to exercise in chronic kidney disease.American journal of physiology. Heart and circulatory physiology · 2023Review
20 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Heart rate and blood pressure are elevated at the onset and throughout the duration of dynamic or static exercise. These neurally mediated cardiovascular adjustments to physical activity are regulated, in part, by a peripheral reflex originating in contracting skeletal muscle termed the exercise pressor reflex. Mechanically sensitive and metabolically sensitive receptors activating the exercise pressor reflex are located on the unencapsulated nerve terminals of group III and group IV afferent sensory neurons, respectively. Mechanoreceptors are stimulated by the physical distortion of their receptive fields during muscle contraction and can be sensitized by the production of metabolites generated by working skeletal myocytes. The chemical by-products of muscle contraction also stimulate metaboreceptors. Once activated, group III and IV sensory impulses are transmitted to cardiovascular control centers within the brain stem where they are integrated and processed. Activation of the reflex results in an increase in efferent sympathetic nerve activity and a withdrawal of parasympathetic nerve activity. These actions result in the precise alterations in cardiovascular hemodynamics requisite to meet the metabolic demands of working skeletal muscle. Coordinated activity by this reflex is altered after the development of cardiovascular disease, generating exaggerated increases in sympathetic nerve activity, blood pressure, heart rate, and vascular resistance. The basic components and operational characteristics of the reflex, the techniques used in human and animals to study the reflex, and the emerging evidence describing the dysfunction of the reflex with the advent of cardiovascular disease are highlighted in this review.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.