ArticleJournal of bacteriology2011
Bacterioopsin-mediated regulation of bacterioruberin biosynthesis in Halobacterium salinarum.
Article in Journal of bacteriology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 59 citations in OpenAlex.
- Carotenoids of Halophilic Archaea: Production, Properties and Biotechnological Applications.Probiotics and antimicrobial proteins · 2026Review
- A New Era for Using Natural Pigments: The Case of the CBiotechnology and applied biochemistry · 2026Review
- Elucidating metabolic pathways through genomic analysis in highly heavy metal-resistantHeliyon · 2024Article
- Genomic insights on carotenoid synthesis by extremely halophilic archaea Haloarcula rubripromontorii BS2, Haloferax lucentense BBK2 and Halogeometricum borinquense E3 isolated from the solar salterns of India.Scientific reports · 2024Article
- Two Distinct Enzymes Have Both Phytoene Desaturase and 3,4-Desaturase Activities Involved in Carotenoid Biosynthesis by the Extremely Halophilic Archaeon Haloarcula japonica.Microbes and environments · 2024Article
- Sustainable production of bacterioruberin carotenoid and its derivatives from Arthrobacter agilis NP20 on whey-based medium: optimization and product characterization.Bioresources and bioprocessing · 2023Article
- Archaea Carotenoids: Natural Pigments with Unexplored Innovative Potential.Marine drugs · 2022Review
- Identification of acetylated diether lipids in halophilic Archaea.MicrobiologyOpen · 2022Article
- Engineered CRISPR/Cas9 System for Transcriptional Gene Silencing in Arthrobacter Species Indicates Bacterioruberin is Indispensable for Growth at Low Temperatures.Current microbiology · 2022Article
- Open Issues for Protein Function Assignment inGenes · 2021Article
- Structural basis for carotenoid cleavage by an archaeal carotenoid dioxygenase.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Acid Experimental Evolution of the HaloarchaeonFrontiers in microbiology · 2020Article
- Extremophilic models for astrobiology: haloarchaeal survival strategies and pigments for remote sensing.Extremophiles : life under extreme conditions · 2020Review
- Haloarchaeal Carotenoids: Healthy Novel Compounds from Extreme Environments.Marine drugs · 2019Review
- Species Widely Distributed in Halophilic Archaea Exhibit Opsin-Mediated Inhibition of Bacterioruberin Biosynthesis.Journal of bacteriology · 2019Article
- In silico and experimental improvement of bacteriorhodopsin production in Halobacterium salinarum R1 by increasing DNA-binding affinity of Bat through Q661R/Q665R substitutions in HTH motif.Extremophiles : life under extreme conditions · 2019Article
- Halobacterium salinarum storage and rehydration after spray drying and optimization of the processes for preservation of carotenoids.Extremophiles : life under extreme conditions · 2018Article
- Complex Effects of Cytochrome P450 Monooxygenase on Purple Membrane and Bacterioruberin Production in an Extremely Halophilic Archaeon: Genetic, Phenotypic, and Transcriptomic Analyses.Frontiers in microbiology · 2018Article
- Opsin-Mediated Inhibition of Bacterioruberin Synthesis in Halophilic Archaea.Journal of bacteriology · 2017Article
- ProCarDB: a database of bacterial carotenoids.BMC microbiology · 2016Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Integral membrane protein complexes consisting of proteins and small molecules that act as cofactors have important functions in all organisms. To form functional complexes, cofactor biosynthesis must be coordinated with the production of corresponding apoproteins. To examine this coordination, we study bacteriorhodopsin (BR), a light-induced proton pump in the halophilic archaeon Halobacterium salinarum. This complex consists of a retinal cofactor and bacterioopsin (BO), the BR apoprotein. To examine possible novel regulatory mechanisms linking BO and retinal biosynthesis, we deleted bop, the gene that encodes BO. bop deletion resulted in a dramatic increase of bacterioruberins, carotenoid molecules that share biosynthetic precursors with retinal. Additional studies revealed that bacterioruberins accumulate in the absence of BO regardless of the presence of retinal or BR, suggesting that BO inhibits bacterioruberin biosynthesis to increase the availability of carotenoid precursors for retinal biosynthesis. To further examine this potential regulatory mechanism, we characterized an enzyme, encoded by the lye gene, that catalyzes bacterioruberin biosynthesis. BO-mediated inhibition of bacterioruberin synthesis appears to be specific to the H. salinarum lye-encoded enzyme, as expression of a lye homolog from Haloferax volcanii, a related archaeon that synthesizes bacterioruberins but lacks opsins, resulted in bacterioruberin synthesis that was not reduced in the presence of BO. Our results provide evidence for a novel regulatory mechanism in which biosynthesis of a cofactor is promoted by apoprotein-mediated inhibition of an alternate biochemical pathway. Specifically, BO accumulation promotes retinal production by inhibiting bacterioruberin biosynthesis.
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