ArticleGenetics2011
Distribution of parental genome blocks in recombinant inbred lines.
Article in Genetics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed.
- Genomic basis of schistosome resistance in a molluscan vector of human schistosomiasis.iScience · 2025Article
- Recursive Algorithms for Modeling Genomic Ancestral Origins in a Fixed Pedigree.G3 (Bethesda, Md.) · 2018Article
- Haldane, Waddington and recombinant inbred lines: extension of their work to any number of genes.Journal of genetics · 2017Article
- Article
- Signatures of Dobzhansky-Muller Incompatibilities in the Genomes of Recombinant Inbred Lines.Genetics · 2016Article
- Modeling X-linked ancestral origins in multiparental populations.G3 (Bethesda, Md.) · 2015Article
- A general modeling framework for genome ancestral origins in multiparental populations.Genetics · 2014Article
- The lengths of admixture tracts.Genetics · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We consider recombinant inbred lines obtained by crossing two given homozygous parents and then applying multiple generations of self-crossings or full-sib matings. The chromosomal content of any such line forms a mosaic of blocks, each alternatively inherited identically by descent from one of the parents. Quantifying the statistical properties of such mosaic genomes has remained an open challenge for many years. Here, we solve this problem by taking a continuous chromosome picture and assuming crossovers to be noninterfering. Using a continuous-time random walk framework and Markov chain theory, we determine the statistical properties of these identical-by-descent blocks. We find that successive block lengths are only very slightly correlated. Furthermore, the blocks on the ends of chromosomes are larger on average than the others, a feature understandable from the nonexponential distribution of block lengths.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.