Trial reportBiological psychiatry2011
The serotonin transporter gene alters sensitivity to attention bias modification: evidence for a plasticity gene.
Trial report in Biological psychiatry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
48 citing papers in PubMed, 131 citations in OpenAlex.
- 5-HTTLPR does not moderate the effect of attention bias modification for depression: a randomized sham-controlled trial.Translational psychiatry · 2025Trial
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- Self-construal and attentional biases in cognitive processing: Insights from Chinese college students for mental health contexts.PLOS mental health · 2024Article
- Noradrenergic gene variation shaping vulnerability and resilience by affecting mental health-related characteristics: A systematic review.Neuroscience applied · 2024Article
- Childhood adversity and approach/avoidance-related behaviour in boys.Journal of neural transmission (Vienna, Austria : 1996) · 2022Article
- Methylation of the serotonin transporter gene moderates the depressive subjective effect of cocaine.Behavioural brain research · 2022Article
- Pharmacogenetics of Addiction Therapy.Methods in molecular biology (Clifton, N.J.) · 2022Article
- A neural model of vulnerability and resilience to stress-related disorders linked to differential susceptibility.Molecular psychiatry · 2022Review
- Article
- Association of TPH1 and serotonin transporter genotypes with treatment response for suicidal ideation: a preliminary study.European archives of psychiatry and clinical neuroscience · 2020Article
- Effect of Gender, Physical Activity and Stress-Related Hormones on Adolescent's Academic Achievements.International journal of environmental research and public health · 2020Article
- Risk and protective effects of serotonin and BDNF genes on stress-related adult psychiatric symptoms.Neurobiology of stress · 2019Article
- Associations Between Attentional Bias and Interpretation Bias and Change in School Concerns and Anxiety Symptoms During the Transition from Primary to Secondary School.Journal of abnormal child psychology · 2019Article
- Article
- The CogBIAS longitudinal study protocol: cognitive and genetic factors influencing psychological functioning in adolescence.BMC psychology · 2017Article
- Vigilance for threat accounts for inter-individual variation in physiological responses to adversity in rhesus macaques: A cognition × environment approach.Developmental psychobiology · 2017Article
- Genetic moderation of cocaine subjective effects by variation in the TPH1, TPH2, and SLC6A4 serotonin genes.Psychiatric genetics · 2017Article
- Serotonin transporter polymorphism moderates the effects of caregiver intrusiveness on ADHD symptoms among institutionalized preschoolers.European child & adolescent psychiatry · 2017Article
- The Serotonin Transporter and Early Life Stress: Translational Perspectives.Frontiers in cellular neuroscience · 2017Review
- 5-HTTLPR polymorphism is linked to neural mechanisms of selective attention in preschoolers from lower socioeconomic status backgrounds.Developmental cognitive neuroscience · 2016Article
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundAttention bias modification (ABM) procedures have been shown to modify biased attention with important implications for emotional vulnerability and resilience. The use of ABM to reduce potentially toxic biases, for instance, is a newly emerging therapy for anxiety disorders. A separate line of gene-by-environment interaction research proposes that many so-called vulnerability genes or risk alleles are better seen as plasticity genes, as they seem to make individuals more susceptible to environmental influences for better and for worse.
methodsA standard ABM procedure was used with a sample of 116 healthy adults. Participants were randomly assigned to one of two training groups. One received an ABM procedure designed to induce a bias in attention toward negative material, while the other was trained toward positive pictures. Individuals with low- and high-expressing forms of the serotonin transporter gene (5-HTTLPR) were compared.
resultsThose with a low-expression form (S/S, S/Lg, or Lg/Lg) of the 5-HTTLPR gene developed stronger biases for both negative and positive affective pictures relative to those with the high-expression (La/La) form of the gene.
conclusionsHere, we report the first evidence that allelic variation in the promotor region of the 5-HTTLPR gene predicts different degrees of sensitivity to ABM. These results suggest a potential cognitive mechanism for the gene-by-environment interactions that have been found in relation to the serotonin transporter gene. Variation on this genotype may therefore determine who will benefit most (and least) from therapeutic interventions, adversity, and supportive environments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.