ArticleJournal of molecular biology2011
Indirect repression by Bacillus subtilis CodY via displacement of the activator of the proline utilization operon.
Article in Journal of molecular biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Harnessing the thermotolerant methylotroph Bacillus methanolicus for methanol-based synthetic L-proline production.Microbial cell factories · 2026Article
- CodY: An Essential Transcriptional Regulator Involved in Environmental Stress Tolerance in FoodborneFoods (Basel, Switzerland) · 2023Article
- Structural insights into CodY activation and DNA recognition.Nucleic acids research · 2023Article
- Understanding and application of Bacillus nitrogen regulation: A synthetic biology perspective.Journal of advanced research · 2023Review
- Regulation of cid and lrg expression by CodY in Streptococcus mutans.MicrobiologyOpen · 2020Article
- Regulation of γ-Aminobutyrate (GABA) Utilization inFrontiers in microbiology · 2020Article
- Role of Proline in Pathogen and Host Interactions.Antioxidants & redox signaling · 2019Review
- CodY, a master integrator of metabolism and virulence in Gram-positive bacteria.Current genetics · 2017Review
- CcpA and CodY Coordinate Acetate Metabolism in Streptococcus mutans.Applied and environmental microbiology · 2017Article
- Structure of the Branched-chain Amino Acid and GTP-sensing Global Regulator, CodY, fromThe Journal of biological chemistry · 2017Article
- Late-Exponential Gene Expression in codY-Deficient Bacillus anthracis in a Host-Like Environment.Current microbiology · 2016Article
- Changes in Bacillus anthracis CodY regulation under host-specific environmental factor deprived conditions.BMC genomics · 2016Article
- Mapping of internal monophosphate 5' ends of Bacillus subtilis messenger RNAs and ribosomal RNAs in wild-type and ribonuclease-mutant strains.Nucleic acids research · 2016Article
- Interactive regulation by the Bacillus subtilis global regulators CodY and ScoC.Molecular microbiology · 2015Article
- Regulating the Intersection of Metabolism and Pathogenesis in Gram-positive Bacteria.Microbiology spectrum · 2015Review
- Role of branched-chain amino acid transport in Bacillus subtilis CodY activity.Journal of bacteriology · 2015Article
- Competition between VanU(G) repressor and VanR(G) activator leads to rheostatic control of vanG vancomycin resistance operon expression.PLoS genetics · 2015Article
- CodY regulates expression of the Bacillus subtilis extracellular proteases Vpr and Mpr.Journal of bacteriology · 2015Article
- Uptake of amino acids and their metabolic conversion into the compatible solute proline confers osmoprotection to Bacillus subtilis.Applied and environmental microbiology · 2015Article
- Hierarchical expression of genes controlled by the Bacillus subtilis global regulatory protein CodY.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
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Authors and funding
1 author.
Funding
Abstract
Proline is an efficient source of both carbon and nitrogen for many bacterial species. In Bacillus subtilis, the proline utilization pathway, encoded by the putBCP operon, is inducible by proline. Here, we show that this induction is mediated by PutR, a proline-responsive transcriptional activator of the PucR family. When other amino acids are present in the medium, proline utilization is prioritized through transient repression by CodY, a global transcriptional regulator in Gram-positive bacteria that responds to amino acid availability. CodY-mediated repression of the putBCP operon has two novel features. First, repression requires the cooperative binding of CodY to at least two adjacent motifs. Second, though CodY binds to the region that overlaps the putB promoter, repression is due to displacement of PutR rather than competition with RNA polymerase.
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