Trial reportPsychoneuroendocrinology2012
Effects of intranasal oxytocin and vasopressin on cooperative behavior and associated brain activity in men.
Trial report in Psychoneuroendocrinology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 138 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
138 citing papers in PubMed, 4 syntheses or guidelines pooled it, 308 citations in OpenAlex.
- The effect of intranasal oxytocin on social reward processing in humans: a systematic review.Frontiers in psychiatry · 2023Pooled it
- The Role of Oxytocin in Antisocial Personality Disorders: A Systematic Review of the Literature.Frontiers in psychiatry · 2019Pooled it
- Neural substrates underlying the effects of oxytocin: a quantitative meta-analysis of pharmaco-imaging studies.Social cognitive and affective neuroscience · 2017Pooled it
- Neurophysiological effects of acute oxytocin administration: systematic review and meta-analysis of placebo-controlled imaging studies.Journal of psychiatry & neuroscience : JPN · 2015Pooled it
- Oxytocin, but not vasopressin, decreases willingness to harm others by promoting moral emotions of guilt and shame.Molecular psychiatry · 2024Trial
- Effects of arginine vasopressin on human anxiety and associations with sex, dose, and V1a-receptor genotype.Psychopharmacology · 2024Trial
- Alarm or emotion? intranasal oxytocin helps determine information conveyed by dog barks for adult male human listeners.BMC ecology and evolution · 2024Trial
- Temporal profile of intranasal oxytocin in the human autonomic nervous system at rest: An electrocardiography and pupillometry study.Journal of psychopharmacology (Oxford, England) · 2023Trial
- Null results of oxytocin and vasopressin administration on mentalizing in a large fMRI sample: evidence from a randomized controlled trial.Psychological medicine · 2023Trial
- Effects of intranasal oxytocin on threat- and reward-related functional connectivity in men and women with and without childhood abuse-related PTSD.Psychiatry research. Neuroimaging · 2021Trial
- Oxytocin treatment attenuates amygdala activity in autism: a treatment-mechanism study with long-term follow-up.Translational psychiatry · 2020Trial
- Oxytocin and vasopressin modulation of prisoner's dilemma strategies.Journal of psychopharmacology (Oxford, England) · 2020Trial
- Oxytocin induces long-lasting adaptations within amygdala circuitry in autism: a treatment-mechanism study with randomized placebo-controlled design.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Trial
- Oxytocin Enhances an Amygdala Circuit Associated With Negative Symptoms in Schizophrenia: A Single-Dose, Placebo-Controlled, Crossover, Randomized Control Trial.Schizophrenia bulletin · 2020Trial
- Null results of oxytocin and vasopressin administration across a range of social cognitive and behavioral paradigms: Evidence from a randomized controlled trial.Psychoneuroendocrinology · 2019Trial
- Vasopressin enhances human preemptive strike in both males and females.Scientific reports · 2019Trial
- MDMA Increases Cooperation and Recruitment of Social Brain Areas When Playing Trustworthy Players in an Iterated Prisoner's Dilemma.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Trial
- Neurobiological Mechanisms of Responding to Injustice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Trial
- Oxytocin Receptor Gene Variant Interacts with Intervention Delivery Format in Predicting Intervention Outcomes for Youth with Conduct Problems.Prevention science : the official journal of the Society for Prevention Research · 2018Trial
- Oxytocin effects on self-referential processing: behavioral and neuroimaging evidence.Social cognitive and affective neuroscience · 2017Trial
78 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 3 countries.
Funding
Abstract
The neural mechanisms supporting social bonds between adult men remain uncertain. In this double-blind, placebo-controlled study, we investigate the impact of intranasally administered oxytocin (OT) and vasopressin (AVP) on behavior and brain activity among men in the context of an iterated Prisoner's Dilemma game, which models a real-life social situation. fMRI results show that, relative to both AVP and placebo, OT increases the caudate nucleus response to reciprocated cooperation, which may augment the reward of reciprocated cooperation and/or facilitate learning that another person can be trusted. OT also enhances left amygdala activation in response to reciprocated cooperation. Behaviorally, OT was associated with increased rates of cooperation following unreciprocated cooperation in the previous round compared with AVP. AVP strongly increased cooperation in response to a cooperative gesture by the partner compared with both placebo and OT. In response to reciprocated cooperation, AVP increased activation in a region spanning known vasopressin circuitry implicated in affiliative behaviors in other species. Finally, both OT and AVP increase amygdala functional connectivity with the anterior insula relative to placebo, which may increase the amygdala's ability to elicit visceral somatic markers that guide decision making. These findings extend our knowledge of the neural and behavioral effects of OT and AVP to the context of genuine social interactions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.