ArticleVirology2011
Cowpox virus infection of cynomolgus macaques as a model of hemorrhagic smallpox.
Article in Virology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 36 citations in OpenAlex.
- Poxviridae Pneumonia.Advances in experimental medicine and biology · 2024Review
- Modeling and analysis of monkeypox disease using fractional derivatives.Results in engineering · 2023Article
- Cowpox Viruses: A Zoo Full of Viral Diversity and Lurking Threats.Biomolecules · 2023Review
- Acute Late-Stage Myocarditis in the Crab-Eating Macaque Model of Hemorrhagic Smallpox.Viruses · 2021Article
- Article
- IMVAMUNEVaccines · 2020Article
- Review
- Article
- Limited susceptibility of rhesus macaques to a cowpox virus isolated from a lethal outbreak among New World monkeys.Primate biology · 2017Article
- Exposure of rhesus monkeys to cowpox virus Brighton Red by large-particle aerosol droplets results in an upper respiratory tract disease.The Journal of general virology · 2016Article
- Small particle aerosol inoculation of cowpox Brighton Red in rhesus monkeys results in a severe respiratory disease.Virology · 2015Article
- Pharmacokinetic and pharmacodynamic modeling to determine the dose of ST-246 to protect against smallpox in humans.Antimicrobial agents and chemotherapy · 2013Article
- Comparison of host cell gene expression in cowpox, monkeypox or vaccinia virus-infected cells reveals virus-specific regulation of immune response genes.Virology journal · 2013Article
- Emergence of cowpox: study of the virulence of clinical strains and evaluation of antivirals.PloS one · 2013Article
- Article
- Cowpox virus but not Vaccinia virus induces secretion of CXCL1, IL-8 and IL-6 and chemotaxis of monocytes in vitro.Virus research · 2013Article
- The non-human primate model of tuberculosis.Journal of medical primatology · 2012Review
- Intrabronchial inoculation of cynomolgus macaques with cowpox virus.The Journal of general virology · 2012Article
- Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Hemorrhagic smallpox was a rare but severe manifestation of variola virus infection that resulted in nearly 100% mortality. Here we describe intravenous (IV) inoculation of cowpox virus Brighton Red strain in cynomolgus macaques (Macaca fascicularis) which resulted in disease similar in presentation to hemorrhagic smallpox in humans. IV inoculation of macaques resulted in a uniformly lethal disease within 12 days post-inoculation in two independent experiments. Clinical observations and hematological and histopathological findings support hemorrhagic disease. Cowpox virus replicated to high levels in blood (8.0-9.0 log(10) gene copies/mL) and tissues including lymph nodes, thymus, spleen, bone marrow, and lungs. This unique model of hemorrhagic orthopoxvirus infection provides an accessible means to further study orthopoxvirus pathogenesis and to identify virus-specific and nonspecific therapies. Such studies will serve to complement the existing nonhuman primate models of more classical poxviral disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.