ArticleDevelopmental biology2011
EBF proteins participate in transcriptional regulation of Xenopus muscle development.
Article in Developmental biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 38 citations in OpenAlex.
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- EBF3 Gene-Related Fetal Phenotypes.Maternal-fetal medicine (Wolters Kluwer Health, Inc.) · 2025Article
- Rbm24-mediated post-transcriptional regulation of skeletal and cardiac muscle development, function and regeneration.Journal of muscle research and cell motility · 2025Review
- A change in cis-regulatory logic underlying obligate versus facultative muscle multinucleation in chordates.Development (Cambridge, England) · 2024Article
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- Early B-cell transcription factor-2 defect as a novel cause of lipodystrophy: disruption of the adipose tissue character and integrity.medRxiv : the preprint server for health sciences · 2024Article
- A change inbioRxiv : the preprint server for biology · 2024Article
- Neuroimaging Findings in Patients withMolecular syndromology · 2021Article
- RNA-Binding Proteins in the Post-transcriptional Control of Skeletal Muscle Development, Regeneration and Disease.Frontiers in cell and developmental biology · 2021Review
- Evolution of Somite Compartmentalization: A View FromFrontiers in cell and developmental biology · 2021Article
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- Zfp423 Regulates Skeletal Muscle Regeneration and Proliferation.Molecular and cellular biology · 2019Article
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- Human Organ-Specific Endothelial Cell Heterogeneity.iScience · 2018Article
- The structure, splicing, synteny and expression of lamprey COE genes and the evolution of the COE gene family in chordates.Development genes and evolution · 2017Article
- Gene regulatory networks and cell lineages that underlie the formation of skeletal muscle.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Novel de novo variant inCold Spring Harbor molecular case studies · 2017Article
- Rewiring of an ancestral Tbx1/10-Ebf-Mrf network for pharyngeal muscle specification in distinct embryonic lineages.Development (Cambridge, England) · 2016Article
- MyoD reprogramming requires Six1 and Six4 homeoproteins: genome-wide cis-regulatory module analysis.Nucleic acids research · 2016Article
- Article
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2 authors at 1 institution in 1 country.
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Abstract
EBF proteins have diverse functions in the development of multiple lineages, including neurons, B cells and adipocytes. During Drosophila muscle development EBF proteins are expressed in muscle progenitors and are required for muscle cell differentiation, but there is no known function of EBF proteins in vertebrate muscle development. In this study, we examine the expression of ebf genes in Xenopus muscle tissue and show that EBF activity is necessary for aspects of Xenopus skeletal muscle development, including somite organization, migration of hypaxial muscle anlagen toward the ventral abdomen, and development of jaw muscle. From a microarray screen, we have identified multiple candidate targets of EBF activity with known roles in muscle development. The candidate targets we have verified are MYOD, MYF5, M-Cadherin and SEB-4. In vivo overexpression of the ebf2 and ebf3 genes leads to ectopic expression of these candidate targets, and knockdown of EBF activity causes downregulation of the endogenous expression of the candidate targets. Furthermore, we found that MYOD and MYF5 are likely to be direct targets. Finally we show that MYOD can upregulate the expression of ebf genes, indicating the presence of a positive feedback loop between EBF and MYOD that we find to be important for maintenance of MYOD expression in Xenopus. These results suggest that EBF activity is important for both stabilizing commitment and driving aspects of differentiation in Xenopus muscle cells.
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