ArticleThe Journal of pediatrics2012
Sensitive diffusion tensor imaging quantification method to identify language pathway abnormalities in children with developmental delay.
Article in The Journal of pediatrics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Altered efficiency of white matter connections for language function in children with language disorder.Brain and language · 2020Article
- Relationship between genotype and arcuate fasciculus morphology in six young children with global developmental delay: Preliminary DTI stuy.Journal of magnetic resonance imaging : JMRI · 2016Article
- Developmental process of the arcuate fasciculus from infancy to adolescence: a diffusion tensor imaging study.Neural regeneration research · 2016Article
- Altered Structural Brain Networks in Tuberous Sclerosis Complex.Cerebral cortex (New York, N.Y. : 1991) · 2016Article
- The Arcuate Fasciculus and Language Development in a Cohort of Pediatric Patients with Malformations of Cortical Development.AJNR. American journal of neuroradiology · 2016Article
- Failure to Identify the Left Arcuate Fasciculus at Diffusion Tractography Is a Specific Marker of Language Dysfunction in Pediatric Patients with Polymicrogyria.Behavioural neurology · 2015Article
- Exome sequencing and diffusion tensor imaging in developmental disabilities.Pediatric research · 2014Article
- Independent contribution of individual white matter pathways to language function in pediatric epilepsy patients.NeuroImage. Clinical · 2014Article
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Authors and funding
7 authors.
Funding
Abstract
objectiveTo investigate whether abnormal regional white matter architecture in the perisylvian region could be used as an easy and sensitive quantitative method to demonstrate language pathway abnormalities in children with developmental delay (DD). STUDY
designWe performed diffusion tensor imaging in 15 DD subjects (age, 61.1 ± 20.9 months) and 15 age-matched typically developing (TD) children (age, 68.4 ± 19.2 months). With diffusion tensor imaging color-coded orientation maps, we quantified the fraction of fibers in the perisylvian region that are oriented in anteroposterior (AP) and mediolateral (ML) directions, and their ratio (AP/ML) was calculated.
resultsThe AP/ML ratio was more sensitive than tractography in characterizing perisylvian regional abnormalities in DD children. The AP/ML ratio of the left perisylvian region was significantly lower in DD children compared with TD children (P = .03). The ML component of bilateral perisylvian regions was significantly higher in DD children compared with TD children (P = .01 [left] and P = .004 [right]). No significant difference was found in the AP component in the two groups. A significant negative correlation of the left ML component with Vineland communication skills was observed (r = -0.657, P = .011).
conclusionsThe AP/ML ratio appears to be a sensitive indicator of regional white matter architectural abnormalities in the perisylvian region of DD children.
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