ArticleThe Journal of pediatrics2012
Body composition abnormalities in long-term survivors of pediatric hematopoietic stem cell transplantation.
Article in The Journal of pediatrics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Body composition after allogeneic haematopoietic cell transplantation/total body irradiation in children and young people: a restricted systematic review.Journal of cancer survivorship : research and practice · 2020Pooled it
- Metabolic Syndrome and Cardiovascular Disease after Hematopoietic Cell Transplantation: Screening and Preventive Practice Recommendations from the CIBMTR and EBMT.Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation · 2016Guideline
- Trial
- EXERCISE in pediatric autologous stem cell transplant patients: a randomized controlled trial protocol.BMC cancer · 2012Trial
- Paediatric cancer survivors: lean mass attenuates negative impact of watching television on bone.Pediatric research · 2025Article
- Article
- Current status of research on sarcopenia in post-treatment cancer survivors in Japan:A narrative review.Fukushima journal of medical science · 2024Review
- Determinants of bone parameters in young paediatric cancer survivors: the iBoneFIT project.Pediatric research · 2023Article
- The role of nutrition in children with cancer.Tumori · 2023Review
- Diabetes in childhood cancer survivors: emerging concepts in pathophysiology and future directions.Frontiers in medicine · 2023Review
- Cardiovascular Risk in Childhood Cancer Survivors.Biomedicines · 2022Review
- Assessment of nutritional status in paediatric outpatients using bioelectrical impedance analysis and anthropometric z-scores.Journal of paediatrics and child health · 2021Article
- Sarcopenia and preserved bone mineral density in paediatric survivors of high-risk neuroblastoma with growth failure.Journal of cachexia, sarcopenia and muscle · 2021Article
- Altered body composition in male long-term survivors of paediatric allogeneic haematopoietic stem cell transplantation: impact of conditioning regimen, chronic graft-versus-host disease and hypogonadism.Bone marrow transplantation · 2021Article
- Brazilian Nutritional Consensus in Hematopoietic Stem Cell Transplantation: children and adolescents.Einstein (Sao Paulo, Brazil) · 2021Article
- Pediatric undernutrition defined by body composition-are we there yet?The American journal of clinical nutrition · 2020Article
- Body Composition, Metabolic Health, and Functional Impairment among Adults Treated for Abdominal and Pelvic Tumors during Childhood.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2020Article
- Optimal Delivery of Follow-Up Care After Allogeneic Hematopoietic Stem-Cell Transplant: Improving Patient Outcomes with a Multidisciplinary Approach.Journal of blood medicine · 2020Review
- Brazilian Nutritional Consensus in Hematopoietic Stem Cell Transplantation: Adults.Einstein (Sao Paulo, Brazil) · 2020Article
- Diabetes and Metabolic Syndrome in Survivors of Childhood Cancer.Hormone research in paediatrics · 2019Review
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
objectiveTo quantify lean mass (LM) and fat mass (FM) in survivors of childhood allogeneic hematopoietic stem-cell transplantation (alloHSCT) compared with healthy reference participants and identify risk factors for body composition abnormalities. STUDY
designWhole body LM and FM were measured with dual energy x-ray absorptiometry in 54 survivors (ages 5-25 years) and 894 healthy reference participants in a cross-sectional study. Multivariate regression models were used to compare sex- and race-specific Z-scores for LM for height (LM-Ht) and FM for height (FM-Ht) in survivors and reference participants and to identify correlates of LM-Ht and FM-Ht Z-scores in alloHSCT.
resultsHeight Z-scores were significantly lower in alloHSCT survivors (P < .001) compared with reference participants; body mass index Z-scores did not differ (P = .13). Survivors had significantly lower mean LM-Ht Z-scores (-0.72; 95% CI, -1.02--0.42; P < .001) and greater FM-Ht Z-scores (1.10; 95% CI, 0.84-1.39; P < .001) compared with reference participants. LM-Ht Z-score deficits in alloHSCT survivors were larger (-1.26; 95% CI, -1.53--0.99; P < .001) after adjustment for FM-Ht Z-scores. Endocrinopathies and alloHSCT characteristics were not associated with LM-Ht or FM-Ht Z-scores.
conclusionSurvivors of childhood alloHSCT have significant LM deficits and FM excess. Future studies should identify the mechanism and consequences of these abnormalities.
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