Trial reportThe Journal of pediatrics2012
Randomized controlled trial of restrictive fluid management in transient tachypnea of the newborn.
Trial report in The Journal of pediatrics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 16 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Multicenter Randomized Controlled Trial Of Restrictive Fluid Management For Respiratory Distress in the Newborn Period
Eficacy and Safety of Restricted Fluid Therapy in Transient Tachypnea of the Newborn: A Randomized Controlled Study
Who cites it
16 citing papers in PubMed, 5 syntheses or guidelines pooled it, 42 citations in OpenAlex.
- Interventions for the management of transient tachypnoea of the newborn - an overview of systematic reviews.The Cochrane database of systematic reviews · 2022Pooled it
- Fluid restriction in the management of transient tachypnea of the newborn.The Cochrane database of systematic reviews · 2021Pooled it
- Salbutamol for transient tachypnea of the newborn.The Cochrane database of systematic reviews · 2021Pooled it
- Epinephrine for transient tachypnea of the newborn.The Cochrane database of systematic reviews · 2016Pooled it
- Restricted versus liberal water intake for preventing morbidity and mortality in preterm infants.The Cochrane database of systematic reviews · 2014Pooled it
- Eficacy and safety of restricted fluid therapy in transient tachypnea of the newborn: a randomized controlled study.BMC pediatrics · 2026Trial
- Investigation of the Effectiveness of First Measured Arterial/Cord Blood Gas and Laboratory Results in Predicting the Treatment Model in Newborns Diagnosed With Transient Tachypnea.Journal of tropical medicine · 2026Article
- Neonatal fluid overload-ignorance is no longer bliss.Pediatric nephrology (Berlin, Germany) · 2023Review
- What happens to 35 week infants that receive delivery room continuous positive airway pressure?Journal of perinatology : official journal of the California Perinatal Association · 2021Article
- Fluid Balance in the Critically Ill Child Section: "How Bad Is Fluid in Neonates?"Frontiers in pediatrics · 2021Review
- Recent Advances in Pathophysiology and Management of Transient Tachypnea of Newborn.Journal of perinatology : official journal of the California Perinatal Association · 2021Review
- Short term outcomes in term and late preterm neonates admitted to the well-baby nursery after resuscitation in the delivery room.Journal of perinatology : official journal of the California Perinatal Association · 2019Article
- Increased incidence of respiratory distress syndrome in neonates of mothers with abnormally invasive placentation.PloS one · 2018Article
- Structural cardiac lesions in transient tachypnea of the newborn.Medical journal, Armed Forces India · 2016Article
- The Effects of Inhaled β-Adrenergic Agonists in Transient Tachypnea of the Newborn.Global pediatric health · 2016Article
- Restricted versus Standard Maintenance Fluid Volume in Management of Transient Tachypnea of Newborn: A Clinical Trial.Iranian journal of pediatrics · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveTo determine the effect of mild fluid restriction on the hospital course of neonates with transient tachypnea of the newborn (TTN). STUDY
designIn this pilot prospective randomized controlled trial of 64 late preterm and term neonates diagnosed with TTN at a single tertiary care hospital in the United States, patients were randomized to receive standard fluid management or mild fluid restriction. The primary outcome was duration of respiratory support. Secondary outcomes were duration of admission to the intensive care unit, time to first enteral feed, and total and composite hospital costs. Results were analyzed by t-test, χ(2) test, Kaplan-Meier estimation, and proportional hazards regression.
resultsFluid restriction did not cause adverse events or unsafe dehydration. Fluid management strategy did not affect primary or secondary outcomes in the total study population. Fluid restriction significantly reduced the duration of respiratory support (P = .008) and hospitalization costs (P = .017) in neonates with severe TTN.
conclusionMild fluid restriction appears to be safe in late preterm and term neonates with uncomplicated TTN. Fluid restriction may be of benefit in decreasing the duration of respiratory support and reducing hospitalization costs in term and late preterm neonates with uncomplicated severe TTN.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.