ReviewSeminars in nephrology2011
Idiopathic membranous nephropathy: an autoimmune disease.
Review in Seminars in nephrology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- IgG4 anti-phospholipase A2 receptor might activate lectin and alternative complement pathway meanwhile in idiopathic membranous nephropathy: an inspiration from a cross-sectional study.Immunologic research · 2016Pooled it
- MHC class II and PLA2R investigating the epitope presentation deficits driving antibody production in membranous nephropathy.International urology and nephrology · 2026Review
- From immune dysregulation to renal injury: mechanistic insights and translational opportunities in immune-mediated nephropathies.Frontiers in cell and developmental biology · 2026Review
- Efficacy and Safety of Rituximab in the Treatment of Idiopathic Membranous Nephropathy: A Meta-Analysis.Applied bionics and biomechanics · 2022Review
- Membranous nephropathy and autoimmune hepatitis in the setting of acute Helicobacter pylori infection: a case report.Journal of medical case reports · 2021Article
- Article
- Tacrolimus Prevents TWEAK-Induced PLA2R Expression in Cultured Human Podocytes.Journal of clinical medicine · 2020Article
- Serum Antibody and Glomerular Antigen of Antiphospholipase A2 Receptor in Chinese Patients with Idiopathic Membranous Nephropathy.BioMed research international · 2020Article
- Serum uric acid is an independent predictor of renal outcomes in patients with idiopathic membranous nephropathy.International urology and nephrology · 2019Article
- Immunological Pathogenesis of Membranous Nephropathy: Focus on PLA2R1 and Its Role.Frontiers in immunology · 2019Review
- Anti-phospholipase A2 receptor antibody as a prognostic marker in patients with primary membranous nephropathy.Kidney research and clinical practice · 2018Article
- Kidney disease models: tools to identify mechanisms and potential therapeutic targets.Zoological research · 2018Review
- Concurrent Presentation of Thrombotic Thrombocytopenic Purpura and Membranous Nephropathy.Kidney international reports · 2018Article
- Clinicopathological features of idiopathic membranous nephropathy combined with IgA nephropathy: a retrospective analysis of 9 cases.Diagnostic pathology · 2016Article
- Membranous glomerulonephritis: histological and serological features to differentiate cancer-related and non-related forms.Journal of nephrology · 2016Review
- Clinical Features and Outcomes in Patients With Membranous Nephropathy and Crescent Formation.Medicine · 2015Observational
- Identification of the immunodominant epitope region in phospholipase A2 receptor-mediating autoantibody binding in idiopathic membranous nephropathy.Journal of the American Society of Nephrology : JASN · 2015Article
- Idiopathic membranous nephropathy and IgG4: an interesting relationship.Clinical nephrology · 2014Review
- Exploring necrotizing autoimmune myopathies with a novel immunoassay for anti-3-hydroxy-3-methyl-glutaryl-CoA reductase autoantibodies.Arthritis research & therapy · 2014Article
- ChIP-seq analysis of histone H3K9 trimethylation in peripheral blood mononuclear cells of membranous nephropathy patients.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2014Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
For more than 50 years researchers have debated the evidence for an autoimmune basis of human idiopathic membranous nephritis (MN). Work published in the past 2 years has substantially strengthened the belief that MN is indeed an autoimmune disease of the kidney. Autoantibodies of the IgG4 subclass to at least three podocyte membrane proteins including phospholipase A(2)-receptor, aldose reductase, and manganese superoxide dismutase have been detected by immunoblotting in sera as well as in acid eluates prepared from renal biopsy tissue of patients with this disease, using either whole tissue or microdissected glomeruli from frozen sections. In each case the podocyte antigen has been shown to co-localize with the subepithelial glomerular immune deposits in renal tissue of the same patients. It is not certain if any of these podocyte proteins is an inciting/primary autoantigen or whether they are secondary antigens recruited by intermolecular epitope-spreading, initiating from a yet-to-be-discovered autoantigen. Although it is clear that autoantibodies to podocyte membrane proteins are elicited in idiopathic MN and contribute to the formation of the subepithelial deposits, many questions remain concerning the triggers for their development and their contribution toward proteinuria and progression of the disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.