ArticleNeuropharmacology2011
Chronic valproate treatment blocks D2-like receptor-mediated brain signaling via arachidonic acid in rats.
Article in Neuropharmacology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 23 citations in OpenAlex.
- The Anticonvulsant Effect of Long-Term Valproate Might Be Attributable to Altered Expression of Selected Genes in Mice.International journal of molecular sciences · 2026Article
- Narrative Review on Common Traits of Parkinson's Disease and Epilepsy.Journal of clinical medicine · 2025Review
- Trimetazidine, an Anti-Ischemic Drug, Reduces the Antielectroshock Effects of Certain First-Generation Antiepileptic Drugs.International journal of molecular sciences · 2022Article
- The Role of CaMKII and ERK Signaling in Addiction.International journal of molecular sciences · 2021Review
- Article
- Complex Combination Pharmacotherapy for Bipolar Disorder: Knowing When Less Is More or More Is Better.Focus (American Psychiatric Publishing) · 2019Review
- Diacylglycerol kinase (DGKA) regulates the effect of the epilepsy and bipolar disorder treatment valproic acid inDisease models & mechanisms · 2018Article
- Impact of diet-derived signaling molecules on human cognition: exploring the food-brain axis.NPJ science of food · 2017Review
- D2-like receptor activation does not initiate a brain docosahexaenoic acid signal in unanesthetized rats.BMC neuroscience · 2014Article
- Lithium and the other mood stabilizers effective in bipolar disorder target the rat brain arachidonic acid cascade.ACS chemical neuroscience · 2014Review
- Chronic valproate attenuates some, but not all, facets of mania-like behaviour in mice.The international journal of neuropsychopharmacology · 2013Article
- Altered fatty acid concentrations in prefrontal cortex of schizophrenic patients.Journal of psychiatric research · 2013Article
- Propylisopropylacetic acid (PIA), a constitutional isomer of valproic acid, uncompetitively inhibits arachidonic acid acylation by rat acyl-CoA synthetase 4: a potential drug for bipolar disorder.Biochimica et biophysica acta · 2013Article
- Chronic clozapine reduces rat brain arachidonic acid metabolism by reducing plasma arachidonic acid availability.Journal of neurochemistry · 2013Article
- Valproate as a treatment for dopamine dysregulation syndrome (DDS) in Parkinson's disease.Journal of neurology · 2013Article
- The synthesis and in vivo pharmacokinetics of fluorinated arachidonic acid: implications for imaging neuroinflammation.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2012Article
- Imaging brain signal transduction and metabolism via arachidonic and docosahexaenoic acid in animals and humans.Brain research bulletin · 2012Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
BACKGROUND AND
objectiveHyperdopaminergic signaling and an upregulated brain arachidonic acid (AA) cascade may contribute to bipolar disorder (BD). Lithium and carbamazepine, FDA-approved for the treatment of BD, attenuate brain dopaminergic D(2)-like (D(2), D(3), and D(4)) receptor signaling involving AA when given chronically to awake rats. We hypothesized that valproate (VPA), with mood-stabilizing properties, would also reduce D(2)-like-mediated signaling via AA.
methodsAn acute dose of quinpirole (1 mg/kg) or saline was administered to unanesthetized rats that had been treated for 30 days with a therapeutically relevant dose of VPA (200 mg/kg/day) or vehicle. Regional brain AA incorporation coefficients, k*, and incorporation rates, J(in), markers of AA signaling and metabolism, were measured by quantitative autoradiography after intravenous [1-(14)C]AA infusion. Whole brain concentrations of prostaglandin (PG)E(2) and thromboxane (TX)B(2) also were measured.
resultsQuinpirole compared to saline significantly increased k* in 40 of 83 brain regions, and increased brain concentrations of PGE(2) in chronic vehicle-treated rats. VPA treatment by itself reduced concentrations of plasma unesterified AA and whole brain PGE(2) and TXB(2), and blocked the quinpirole-induced increments in k* and PGE(2).
conclusionThese results further provide evidence that mood stabilizers downregulate brain dopaminergic D(2)-like receptor signaling involving AA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.