ArticleBMC genomics2011
Attenuation of virulence in an apicomplexan hemoparasite results in reduced genome diversity at the population level.
Article in BMC genomics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 38 citations in OpenAlex.
- A conserved motif in the immune-subdominant RAP-1 related antigen ofFrontiers in immunology · 2024Article
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- Identification of CCp5 and FNPA as Novel Non-canonical Members of the CCp Protein Family inFrontiers in veterinary science · 2022Article
- A Culture-Adapted Strain ofFrontiers in cellular and infection microbiology · 2022Article
- Recent Advances in Molecular Genetic Tools forVeterinary sciences · 2021Review
- An Overview of Current Knowledge onFrontiers in veterinary science · 2020Review
- Investigation into limiting dilution and tick transmissibility phenotypes associated with attenuation of the S24 vaccine strain.Parasites & vectors · 2019Article
- Interplay between Attenuation- and Virulence-Factors ofPathogens (Basel, Switzerland) · 2019Review
- Unravelling the cellular and molecular pathogenesis of bovine babesiosis: is the sky the limit?International journal for parasitology · 2019Review
- Spherical Body Protein 2 truncated copy 11 as a specific Babesia bovis attenuation marker.Parasites & vectors · 2018Article
- Genome-wide analysis of gene expression and protein secretion of Babesia canis during virulent infection identifies potential pathogenicity factors.Scientific reports · 2017Article
- Tick passage results in enhanced attenuation of Babesia bovis.Infection and immunity · 2014Article
- Babesia spp. in European wild ruminant species: parasite diversity and risk factors for infection.Veterinary research · 2014Article
- Comparative transcriptome analysis of geographically distinct virulent and attenuated Babesia bovis strains reveals similar gene expression changes through attenuation.BMC genomics · 2013Article
- Loss of neurovirulence is associated with reduction of cerebral capillary sequestration during acute Babesia bovis infection.Parasites & vectors · 2013Review
- EuPathDB: the eukaryotic pathogen database.Nucleic acids research · 2013Article
- Characterization of the unusual bidirectional ves promoters driving VESA1 expression and associated with antigenic variation in Babesia bovis.Eukaryotic cell · 2012Article
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundVirulence acquisition and loss is a dynamic adaptation of pathogens to thrive in changing milieus. We investigated the mechanisms of virulence loss at the whole genome level using Babesia bovis as a model apicomplexan in which genetically related attenuated parasites can be reliably derived from virulent parental strains in the natural host. We expected virulence loss to be accompanied by consistent changes at the gene level, and that such changes would be shared among attenuated parasites of diverse geographic and genetic background.
resultsSurprisingly, while single nucleotide polymorphisms in 14 genes distinguished all attenuated parasites from their virulent parental strains, all non-synonymous changes resulted in no deleterious amino acid modification that could consistently be associated with attenuation (or virulence) in this hemoparasite. Interestingly, however, attenuation significantly reduced the overall population's genome diversity with 81% of base pairs shared among attenuated strains, compared to only 60% of base pairs common among virulent parental parasites. There were significantly fewer genes that were unique to their geographical origins among the attenuated parasites, resulting in a simplified population structure among the attenuated strains.
conclusionsThis simplified structure includes reduced diversity of the variant erythrocyte surface 1 (ves) multigene family repertoire among attenuated parasites when compared to virulent parental strains, possibly suggesting that overall variance in large protein families such as Variant Erythrocyte Surface Antigens has a critical role in expression of the virulence phenotype. In addition, the results suggest that virulence (or attenuation) mechanisms may not be shared among all populations of parasites at the gene level, but instead may reflect expansion or contraction of the population structure in response to shifting milieus.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.