Evidence map›Paper›PMID 21838601›Full record

ArticleJournal of perinatal medicine2011

NICU admission hypothermia, chorioamnionitis, and cytokines.

Karen D Fairchild, Chen-Chih J Sun, George C Gross, Adora C Okogbule-Wonodi, Rose M Chasm, Rose M Viscardi

Abstract read
In one paragraph

Article in Journal of perinatal medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Predicting the likelihood of lower respiratory tractArchives of disease in childhood. Fetal and neonatal edition · 2023
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Karen D FairchildDepartment of Pediatrics, University of Virginia School of Medicine, Charlottesville, VA, USA. kdf2n@virginia.edu
Chen-Chih J Sun
George C Gross
Adora C Okogbule-Wonodi
Rose M Chasm
Rose M Viscardi
University of Maryland, Baltimore · USUniversity of Virginia · US

Funding

Role of TLR Signaling in Ureaplasma-Mediated Neonatal Lung InjuryR01HL087166 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI VISCARDI, ROSE MARIE · 2007 to 2011
$1.8M
Hypothermia enhances inflammatory cytokine expression via NF-kappa BK08HD051609 · NICHD · UNIVERSITY OF VIRGINIA · PI FAIRCHILD, KAREN D · 2006 to 2010
$651k
Determinants of Ureaplasma-mediated neonatal lung injuryR01HL071113 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI VISCARDI, ROSE MARIE · 2002 to 2003
$365k
NHLBI NIH HHS HL071113NHLBI NIH HHS HL087166NHLBI NIH HHS R01 HL071113NHLBI NIH HHS R01 HL087166NICHD NIH HHS HD051609NICHD NIH HHS K08 HD051609
6 · The paper itself

Abstract

objectiveTo determine whether neonatal intensive care unit (NICU) admission hypothermia is associated with an intrauterine inflammatory response.

methodsWe analyzed a cohort of 309 very low birthweight infants to determine relationships between admission hypothermia, chorioamnionitis, and serum and cerebrospinal fluid (CSF) interleukin (IL)-1β, IL-6, and tumor necrosis factor-α.

resultsAdmission hypothermia <36°C occurred in 72% of patients <26 weeks and 44% of patients ≥26 weeks gestational age. NICU admission hypothermia was not associated with histologic chorioamnionitis or with elevated serum cytokine concentrations. CSF IL-6 concentrations ≥6.3 pg/mL were associated with admission hypothermia in infants <26 weeks' gestation. Clinical chorioamnionitis was associated with a lower risk of admission hypothermia, while cesarean section delivery was associated with increased risk.

conclusionsNICU admission hypothermia is common among preterm infants and is not associated with the fetal inflammatory response syndrome. Hypothermia is less common in the setting of clinical chorioamnionitis and more common in cesarean section deliveries, identifying two groups in whom extra attention to appropriate thermoregulation is warranted.

Indexed as

ChorioamnionitisCohort StudiesCytokinesFemaleHumansHypothermiaInfant, NewbornInfant, Very Low Birth WeightIntensive Care, NeonatalIntensive Care Units, NeonatalInterleukin-1betaInterleukin-6MalePatient AdmissionPregnancyProspective StudiesCytokinesIL6 protein, humanInterleukin-1betaInterleukin-6Tumor Necrosis Factor-alpha

Identifiers

PMID21838601
PMCPMC4026090
OpenAlexW2085746798

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.