ArticleThe Biochemical journal1990
Nitric oxide is inactivated by the bacterial pigment pyocyanin.
Article in The Biochemical journal, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 48 citations in OpenAlex.
- Nitric Oxide Tunes Secreted Metabolite Bioactivity.Molecular microbiology · 2026Article
- Nitric oxide tunes secreted metabolite bioactivity.bioRxiv : the preprint server for biology · 2025Article
- No Correlation between Biofilm Formation, Virulence Factors, and Antibiotic Resistance inAntibiotics (Basel, Switzerland) · 2021Article
- Pyocyanin induced in vitro oxidative damage and its toxicity level in human, fish and insect cell lines for its selective biological applications.Cytotechnology · 2016Article
- Reduced nasal nitric oxide production in cystic fibrosis patients with elevated systemic inflammation markers.PloS one · 2013Article
- Redox warfare between airway epithelial cells and Pseudomonas: dual oxidase versus pyocyanin.Immunologic research · 2009Article
- Functional analysis of genes for biosynthesis of pyocyanin and phenazine-1-carboxamide from Pseudomonas aeruginosa PAO1.Journal of bacteriology · 2001Article
- Nitric oxide metabolites in cystic fibrosis lung disease.Archives of disease in childhood · 1998Article
- Perspectives series: host/pathogen interactions. Mechanisms of nitric oxide-related antimicrobial activity.The Journal of clinical investigation · 1997Review
- Electrospray mass-spectrometric, spectrophotometric and electrochemical methods do not provide evidence for the binding of nitric oxide by pyocyanine at pH 7.The Biochemical journal · 1997Article
- Role of oxidants in microbial pathophysiology.Clinical microbiology reviews · 1997Review
- Reduced upper airway nitric oxide in cystic fibrosis.Archives of disease in childhood · 1996Article
- Nitric oxide.Annals of the rheumatic diseases · 1996Review
- Pyocyanin from Pseudomonas aeruginosa inhibits prostacyclin release from endothelial cells.Infection and immunity · 1995Article
- Mechanisms of action of Pseudomonas aeruginosa pyocyanin on human ciliary beat in vitro.Infection and immunity · 1993Article
- Nitric oxide synthase in macula densa regulates glomerular capillary pressure.Proceedings of the National Academy of Sciences of the United States of America · 1992Article
- Effect of pyocyanine, a pigment of Pseudomonas aeruginosa, on production of reactive nitrogen intermediates by murine alveolar macrophages.Infection and immunity · 1992Article
- Modulation of the pharmacological actions of nitrovasodilators by methylene blue and pyocyanin.British journal of pharmacology · 1992Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pyocyanin is a phenazine pigment produced by the bacterium Pseudomonas aeruginosa and found in human lung secretions. Micromolar concentrations of pyocyanin inhibited the bioactivity of endothelium-derived relaxing factor (EDRF) generated from bovine pulmonary-artery endothelium in response to bradykinin. This inhibition was reversed by perfusing the EDRF-bioassay system with pyocyanin-free buffer for 15 min, but persisted in the presence of superoxide dismutase (20 units/ml). When nitric oxide, the major component of EDRF, was passed into an aqueous solution of pyocyanin in the absence of O2, a rapid colour change occurred from blue to pink; m.s. analysis of the products showed that the pyocyanin had been converted into a nitrosylated species.
Indexed as
Identifiers
2183789PMC1131227W181514091What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.