Evidence map›Paper›PMID 21837725›Full record

ReviewWiley interdisciplinary reviews. Nanomedicine and nanobiotechnology

Nanotherapeutic approaches for the treatment of rheumatoid arthritis.

Christine T N Pham

Abstract readReview
In one paragraph

Review in Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Christine T N PhamDivision of Rheumatology, Washington University School of Medicine, Saint Louis, MO, USA. cpham@dom.wustl.edu.

Funding

Characterization/bioinformatics-modeling of nanoparticle:complement interactionsU01NS073457 · NINDS · WASHINGTON UNIVERSITY · PI HOURCADE, DENNIS EMIL · 2010 to 2012
$3.0M
TARGETED NANOTHERAPY IN THE TREATMENT OF INFLAMMATORY ARTHRITISR01AR056468 · NIAMS · WASHINGTON UNIVERSITY · PI PHAM, CHRISTINE T. · 2008 to 2012
$1.6M
NIAMS NIH HHS R01 AR056468NINDS NIH HHS U01 NS073457
6 · The paper itself

Abstract

Rheumatoid arthritis (RA) is a common inflammatory disease characterized by progressive bone and cartilage destruction, resulting in severe functional limitations, shortened lifespan, and increased mortality rates. Recent advances and new treatment approaches have significantly delayed disease progression and improved the quality of life for many patients. Yet few patients attain or can be maintained in disease remission without continuous immunosuppressive therapy. In addition, a sizable portion of patients also fails to respond or eventually develops tolerance to current therapies. Thus there is a continued need for the development of new therapeutic strategies for the treatment of RA. Unlike conventional drugs, nanosystems are designed to deliver therapeutic agents specifically to the site of inflammation, therefore avoiding potential systemic and off-target unwanted effects. They allow investigators to consider or reconsider therapeutic agents that were previously deemed too toxic to deliver through a systemic route. This article reviews recent nanotechnology-based strategies that are being developed for the treatment of inflammatory arthritis.

Indexed as

Arthritis, RheumatoidNanomedicineDrug Delivery SystemsGenetic TherapyHumansNanostructures

Identifiers

PMID21837725
PMCPMC3800699

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.