ReviewDer Pathologe2011
[Clinical aspects of premalignant lesions of the upper gastrointestinal tract].
Review in Der Pathologe, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed, 0 citations in OpenAlex.
No citing paper in PubMed yet.
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A variety of somatic genetic and epigenetic aberrations are discussed in the multistep carcinogenesis of tumors of the upper gastrointestinal tract but specific genetic changes are still unknown. Primary prevention of cancer is important and includes the control of causal endo- and exogenous factors. Screening endoscopies to detect premalignant lesions or early carcinoma cannot be recommended in the Western world. The incidence of preinvasive neoplasia, above all the high-grade intraepithelial neoplasia, in Barrett's esophagus or stomach is as low as 4.0 or 0.6%, respectively. Secondary prevention of cancer after changes of the mucosa should be performed by endoscopic diagnosis and treatment performing biopsies or resection of the lesion. After histological diagnosis of a high-grade intraepithelial neoplasia, complete resection of these lesions including complete ablation of Barrett's mucosa should be carried out. On the basis of an exact pathological report, close cooperation between endoscopist and surgeon seems to be necessary to find out the best individual therapy with curative intent.
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