ArticleJournal of aging research2011
Connecting cerebral white matter lesions and hypertensive target organ damage.
Article in Journal of aging research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
13 citing papers in PubMed, 33 citations in OpenAlex.
- Late Cognitive or Mood Alterations With 'Status Cribrosum' and Diffuse White Matter Lesions: A New Cerebral Small Vessel Disease Phenotype Associated With Rare COL4A1 Variants Located Within Exon 23.European journal of neurology · 2026Article
- The clinical and neuropsychological profiles of Alzheimer's disease with white matter hyperintensity in North China.Frontiers in neurology · 2024Article
- A pathway linking pulse pressure to dementia in adults with Down syndrome.Brain communications · 2024Article
- Pathways linking pulse pressure to dementia in adults with Down syndrome.medRxiv : the preprint server for health sciences · 2023Article
- Ferroptosis: New Dawn for Overcoming the Cardio-Cerebrovascular Diseases.Frontiers in cell and developmental biology · 2021Review
- Article
- Cerebral Small Vessel Disease Associated with Subclinical Vascular Damage Indicators in Asymptomatic Hypertensive Patients.Behavioral sciences (Basel, Switzerland) · 2019Article
- Uncoupling of Microvascular Blood Flow and Capillary Density in Vascular Cognitive Impairment.Frontiers in neurology · 2019Article
- Hypertension and Other Determinants of White Matter Lesions in Stroke Patients.Journal of clinical hypertension (Greenwich, Conn.) · 2016Article
- A combined measure of vascular risk for white matter lesions.Journal of Alzheimer's disease : JAD · 2015Article
- Different locations but common associations in subcortical hypodensities of presumed vascular origin: cross-sectional study on clinical and neurosonologic correlates.BMC neurology · 2014Article
- Urinary albumin to creatinine ratio as potential biomarker for cerebral microvascular disease.Current neurovascular research · 2014Article
- Obesity and metabolic syndrome and functional and structural brain impairments in adolescence.Pediatrics · 2012Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chronic hypertension leads to concomitant remodeling of the cardiac and vascular systems and various organs, especially the brain, kidney, and retina. The brain is an early target of organ damage due to high blood pressure, which is the major modifiable risk factor for stroke and small vessel disease. Stroke is the second leading cause of death and the number one cause of disability worldwide and over 80% of strokes occur in the elderly. Preclinical hypertensive lesions in most target organs are clearly identified: left ventricular hypertrophy for the heart, microalbuminuria for the kidney, fundus abnormalities for the eye, and intima-media thickness and pulse wave velocity for the vessels. However, early hypertensive brain damage is not fully studied due to difficulties in access and the expense of techniques. After age, hypertension is the most-important risk factor for cerebral white matter lesions, which are an important prognostic factor for stroke, cognitive impairment, dementia, and death. Studies have shown an association between white matter lesions and a number of extracranial systems affected by high BP and also suggest that correct antihypertensive treatment could slow white matter lesions progression. There is strong evidence that cerebral white matter lesions in hypertensive patients should be considered a silent early marker of brain damage.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.