ArticleEuropean journal of trauma and emergency surgery : official publication of the European Trauma Society2011
Isolated blunt chest injury leads to transient activation of circulating neutrophils.
Article in European journal of trauma and emergency surgery : official publication of the European Trauma Society, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Neutrophil cell surface receptor dynamics following trauma: a systematic review.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2025Pooled it
- Traumatic Injury and Exposure to Mitochondrial-Derived Damage Associated Molecular Patterns Suppresses Neutrophil Extracellular Trap Formation.Frontiers in immunology · 2019Trial
- Injury to the thorax is a dominant contributor to post-traumatic neutrophil mediated inflammatory response.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2026Article
- Article
- Visualization of the inflammatory response to injury by neutrophil phenotype categories : Neutrophil phenotypes after trauma.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2023Article
- Standardized porcine unilateral femoral nailing is associated with changes in PMN activation status, rather than aberrant systemic PMN prevalence.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2022Article
- Describing Characteristics and Differences of Neutrophils in Sepsis, Trauma, and Control Patients in Routinely Measured Hematology Data.Biomedicines · 2022Article
- Immune modulation after traumatic brain injury.Frontiers in medicine · 2022Review
- Article
- Therapeutic Potential of Mesenchymal Stromal Cell-Derived Extracellular Vesicles in the Prevention of Organ Injuries Induced by Traumatic Hemorrhagic Shock.Frontiers in immunology · 2021Review
- New automated analysis to monitor neutrophil function point-of-care in the intensive care unit after trauma.Intensive care medicine experimental · 2020Article
- Ethyl Pyruvate Reduces Systemic Leukocyte Activation via Caspase-1 and NF-κB After Blunt Chest Trauma and Haemorrhagic Shock.Frontiers in medicine · 2020Article
- Inflammation, Thrombosis, and Destruction: The Three-Headed Cerberus of Trauma- and SARS-CoV-2-Induced ARDS.Frontiers in immunology · 2020Review
- Alcohol Binge Reduces Systemic Leukocyte Activation and Pulmonary PMN Infiltration After Blunt Chest Trauma and Hemorrhagic Shock.Inflammation · 2019Article
- Does Neutrophil Phenotype Predict the Survival of Trauma Patients?Frontiers in immunology · 2019Review
- Neutrophil heterogeneity and its role in infectious complications after severe trauma.World journal of emergency surgery : WJES · 2019Review
- Neutrophils in Tissue Trauma of the Skin, Bone, and Lung: Two Sides of the Same Coin.Journal of immunology research · 2018Review
- MDSCs are induced after experimental blunt chest trauma and subsequently alter antigen-specific T cell responses.Scientific reports · 2017Article
- Prehospital immune responses and development of multiple organ dysfunction syndrome following traumatic injury: A prospective cohort study.PLoS medicine · 2017Article
- Sera from severe trauma patients with pneumonia and without infectious complications have differential effects on neutrophil biology.BMC pulmonary medicine · 2016Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe acute respiratory distress syndrome (ARDS) is a severe and frequently seen complication in multi-trauma patients. ARDS is caused by an excessive innate immune response with a clear role for neutrophils. As ARDS is more frequently seen in trauma patients with chest injury, we investigated the influence of chest injury on the systemic neutrophil response and the development of ARDS. MATERIALS AND
methodsThirteen patients with isolated blunt chest injury [abbreviated injury score (AIS) 2-5] were included. To avoid systemic inflammation caused by tissue damage outside the thorax, injuries to other regions than the chest did not exceed an AIS of 2. At 3, 9 and 24 h after injury, the expression of circulating activating molecules on neutrophils and levels of circulating interleukine (IL)-6 were determined. Blood samples from eight healthy volunteers were used as control.
resultsBlunt chest injury resulted in the activation of circulating neutrophils, as characterized by a decreased expression of l-selectin (CD62L), CXCR2 (CD182b) and C5aR (CD88) compared to control (p < 0.05). Expression of l-selectin, CXCR2 and C5aR was partially restored at 24 h after injury. In addition, the mean expression of FcγRIII (CD16) dropped (p < 0.001), indicating the recruitment of young neutrophils into the circulation. IL-6 levels increased to a maximum mean concentration of 86 ± 31 pg/ml at 24 h postinjury. None of the patients developed ARDS.
conclusionBlunt chest trauma caused a systemic inflammatory reaction with transient activation of neutrophils and mobilization of young neutrophils into the circulation. Isolated chest injury, however, was not abundant enough to cause ARDS, so a second hit appears crucial.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.