ReviewInfectious diseases in obstetrics and gynecology2011
Multipurpose prevention technologies: biomedical tools to prevent HIV-1, HSV-2, and unintended pregnancies.
Review in Infectious diseases in obstetrics and gynecology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 3 syntheses or guidelines pooled it, 94 citations in OpenAlex.
- Strategies for improving postpartum contraceptive use: evidence from non-randomized studies.The Cochrane database of systematic reviews · 2014Pooled it
- Behavioral interventions for improving dual-method contraceptive use.The Cochrane database of systematic reviews · 2014Pooled it
- Behavioral interventions for improving condom use for dual protection.The Cochrane database of systematic reviews · 2013Pooled it
- User-identified gel characteristics: a qualitative exploration of perceived product efficacy of topical vaginal microbicides.Archives of sexual behavior · 2014Trial
- Cervical and systemic innate immunity predictors of HIV risk linked to genital herpes acquisition and time from HSV-2 seroconversion.Sexually transmitted infections · 2023Article
- Development of multipurpose technologies products for pregnancy and STI prevention: update on polyphenylene carboxymethylene MPT gel development†.Biology of reproduction · 2020Article
- Relating Advanced Electrospun Fiber Architectures to the Temporal Release of Active Agents to Meet the Needs of Next-Generation Intravaginal Delivery Applications.Pharmaceutics · 2019Review
- "We are not the same": African women's view of multipurpose prevention products in the TRIO clinical study.International journal of women's health · 2019Article
- Relational underpinnings of condom use: Findings from the project on partner dynamics.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2017Article
- Article
- Triple combination MPT vaginal microbicide using curcumin and efavirenz loaded lactoferrin nanoparticles.Scientific reports · 2016Article
- HIV prevention and research considerations for women in sub-Saharan Africa: moving toward biobehavioral prevention strategies.African journal of reproductive health · 2014Article
- Prevalence and correlates of bacterial vaginosis in different sub-populations of women in sub-Saharan Africa: a cross-sectional study.PloS one · 2014Article
- Designing preclinical perceptibility measures to evaluate topical vaginal gel formulations: relating user sensory perceptions and experiences to formulation properties.AIDS research and human retroviruses · 2014Article
- Assessing the effect of hormonal contraception on HIV acquisition in observational data: challenges and recommended analytic approaches.AIDS (London, England) · 2013Review
- Preventing HIV among young people: research priorities for the future.Journal of acquired immune deficiency syndromes (1999) · 2013Review
- How much demand for New HIV prevention technologies can we really expect? Results from a discrete choice experiment in South Africa.PloS one · 2013Article
- Safety and pharmacokinetics of aciclovir in women following release from a silicone elastomer vaginal ring.The Journal of antimicrobial chemotherapy · 2012Article
- Vaginal rings for delivery of HIV microbicides.International journal of women's health · 2012Article
- Living with uncertainty: acting in the best interests of women.AIDS research and treatment · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Statistics clearly show an unmet need for highly effective contraception, especially in less developed countries. Many of these countries are at the core of the HIV/AIDS epidemic and show very high prevalence rates for other sexually transmitted infections (STIs) such as that caused by HSV-2. A woman at risk of unintended pregnancy due to unprotected intercourse is also at risk for HIV/STI. Owing to their causative interrelationship, combining protection against these conditions will result in enhanced prevention and health benefits. Existing multipurpose prevention modalities such as condoms and physical barriers, albeit efficacious, face cultural hurdles that have so far hindered their widespread use. Success has recently been demonstrated in large clinical trials, demonstrating proof of concept of microbicides in reducing the incidence of HIV-1 and HSV-2 among at-risk populations. The challenge heretofore is to refine these products to make them more potent, convenient, accessible, and acceptable. Potent antiviral drugs released topically in the female reproductive tract by innovative delivered systems and formulations will provide safe, effective, and acceptable multipurpose prevention tools. This paper provides an overview of existing and novel approaches to multipurpose prevention strategies.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.