ArticleThe American journal of pathology1990
Modulation of actin isoform expression in alveolar myofibroblasts (contractile interstitial cells) during pulmonary hypertension.
Article in The American journal of pathology, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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Who cites it
18 citing papers in PubMed, 100 citations in OpenAlex.
- PHD2 deletion in endothelial or arterial smooth muscle cells reveals vascular cell type-specific responses in pulmonary hypertension and fibrosis.Angiogenesis · 2022Article
- Distinct roles of KLF4 in mesenchymal cell subtypes during lung fibrogenesis.Nature communications · 2021Article
- Development of pulmonary fibrosis after heart failure induced by elevated left atrial pressure.American journal of translational research · 2020Article
- Echocardiographic validation of pulmonary hypertension due to heart failure with reduced ejection fraction in mice.Scientific reports · 2018Article
- Deformation-induced transitional myofibroblasts contribute to compensatory lung growth.American journal of physiology. Lung cellular and molecular physiology · 2017Article
- Active Traction Force Response to Long-Term Cyclic Stretch Is Dependent on Cell Pre-stress.Biophysical journal · 2016Article
- Article
- Genomic differences distinguish the myofibroblast phenotype of distal lung fibroblasts from airway fibroblasts.American journal of respiratory cell and molecular biology · 2011Article
- Do two mutually exclusive gene modules define the phenotypic diversity of mammalian smooth muscle?Molecular genetics and genomics : MGG · 2008Article
- Developmental expression of the alpha-skeletal actin gene.BMC evolutionary biology · 2008Article
- c-MET expression in myofibroblasts: role in autocrine activation and prognostic significance in lung adenocarcinoma.The American journal of pathology · 2001Article
- Placental villous stroma as a model system for myofibroblast differentiation.Histochemistry and cell biology · 1996Article
- The monoclonal antibody GB 42--a useful marker for the differentiation of myofibroblasts.Cell and tissue research · 1995Article
- Heterogeneity of myofibroblast phenotypic features: an example of fibroblastic cell plasticity.Virchows Archiv : an international journal of pathology · 1994Review
- Rat alveolar myofibroblasts acquire alpha-smooth muscle actin expression during bleomycin-induced pulmonary fibrosis.The American journal of pathology · 1993Article
- Transforming growth factor-beta 1 induces alpha-smooth muscle actin expression in granulation tissue myofibroblasts and in quiescent and growing cultured fibroblasts.The Journal of cell biology · 1993Article
- The versatility of microvascular pericytes: from mesenchyme to smooth muscle?Histochemistry · 1993Review
- The vascular smooth muscle alpha-actin gene is reactivated during cardiac hypertrophy provoked by load.The Journal of clinical investigation · 1991Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Lungs of 37 patients with pulmonary hypertension (PHT), 5 normal human lungs, and 30 normal rat lungs, were studied using immunohistochemical stainings for actin, alpha-smooth muscle (alpha-SM) actin and desmin. The type of PHT was determined on clinicopathologic grounds (in 17 cases by catheterism); 20 patients had precapillary and 17 postcapillary PHT. In normal lungs, myofibroblasts, ie, contractile interstitial cells (CIC), distributed in alveolar septa, were not stained by alpha-SM actin antibodies. Only around the venules, were cells labeled by this antibody present. Furthermore, there were bundles of alpha-SM actin-positive cells around the openings of air sacculi into the alveolar ducts. In precapillary PHT, the distribution and immunostaining properties of interstitial cells remained unchanged; alpha-SM actin-positive cells were observed in thickened arterial intima and in plexiform lesions. In postcapillary PHT secondary to heart failure, to mitral stenosis, or in veno-occlusive disease, many interstitial cells in the alveolar septa were decorated by alpha-SM actin antibodies but not with desmin. The authors propose that, in postcapillary PHT, mechanical stretch due to capillary congestion may be responsible for the generation of cells that express an actin isoform associated with smooth muscle.
Indexed as
Identifiers
2183626PMC1877630W1244955178What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.