ArticleCirculation. Cardiovascular imaging2011
Molecular MRI of acute necrosis with a novel DNA-binding gadolinium chelate: kinetics of cell death and clearance in infarcted myocardium.
Article in Circulation. Cardiovascular imaging, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 57 citations in OpenAlex.
- Trial
- Biomedical Imaging in Experimental Models of Cardiovascular Disease.Circulation research · 2022Review
- Acute Cardiac Unloading and Recovery: Proceedings of the 4th Annual Acute Cardiac Unloading and REcovery (A-CURE) symposium held on 30 August 2019 in Paris, France.Interventional cardiology (London, England) · 2019Article
- SPECT Imaging of Treatment-Related Tumor Necrosis Using Technetium-99m-Labeled Rhein.Molecular imaging and biology · 2019Article
- Updated developments on molecular imaging and therapeutic strategies directed against necrosis.Acta pharmaceutica Sinica. B · 2019Article
- Molecular Imaging of the Heart.Comprehensive Physiology · 2019Review
- Chemistry of MRI Contrast Agents: Current Challenges and New Frontiers.Chemical reviews · 2019Review
- Identification of protein complexes associated with myocardial infarction using a bioinformatics approach.Molecular medicine reports · 2018Article
- Evaluation of Necrosis Avidity and Potential for Rapid Imaging of Necrotic Myocardium of Radioiodinated Hypocrellins.Molecular imaging and biology · 2018Article
- Multiplexed Optical Imaging of Energy Substrates Reveals That Left Ventricular Hypertrophy Is Associated With Brown Adipose Tissue Activation.Circulation. Cardiovascular imaging · 2018Review
- Review
- Preclinical Evaluation of Radioiodinated Hoechst 33258 for Early Prediction of Tumor Response to Treatment of Vascular-Disrupting Agents.Contrast media & molecular imaging · 2018Article
- Diffusion MRI in the heart.NMR in biomedicine · 2017Review
- NovelACS medicinal chemistry letters · 2017Article
- Theranostic Nucleic Acid Binding Nanoprobe Exerts Anti-inflammatory and Cytoprotective Effects in Ischemic Injury.Theranostics · 2017Article
- A Janus Chelator Enables Biochemically Responsive MRI Contrast with Exceptional Dynamic Range.Journal of the American Chemical Society · 2016Article
- Functional and anatomical characterization of brown adipose tissue in heart failure with blood oxygen level dependent magnetic resonance.NMR in biomedicine · 2016Article
- Molecular Magnetic Resonance Imaging of Tumor Response to Therapy.Scientific reports · 2015Article
- Seeing What We Build--The Need for New Imaging Techniques in Myocardial Regeneration.Journal of the American Heart Association · 2015Article
- MR imaging probes: design and applications.Dalton transactions (Cambridge, England : 2003) · 2015Review
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundCurrent techniques to image cell death in the myocardium are largely nonspecific. We report the use of a novel DNA-binding gadolinium chelate (Gd-TO) to specifically detect the exposed DNA in acutely necrotic (ruptured) cells in vivo. METHODS AND
resultsIn vivo MRI was performed in 20 mice with myocardial infarction (MI). The mice were injected with Gd-TO or Gd-DTPA at varying time points after MI. MRI was performed 2 hours after probe injection, to avoid nonspecific signal from the late gadolinium enhancement effect. Cell rupture (Gd-TO uptake) was present within 2 hours of infarction but peaked 9 to 18 hours after the onset of injury. A significant increase in the longitudinal relaxation rate (R(1)) in the infarct was seen in mice injected with Gd-TO within 48 hours of MI, but not in those injected more than 72 hours after MI (R(1)=1.24±0.08 and 0.92±0.03 s(-1), respectively, P<0.001). Gd-DTPA, unlike Gd-TO, washed completely out of acute infarcts within 2 hours of injection (P<0.001). The binding of Gd-TO to exposed DNA in acute infarcts was confirmed with fluorescence microscopy.
conclusionsGd-TO specifically binds to acutely necrotic cells and can be used to image the mechanism and chronicity of cell death in injured myocardium. Cell rupture in acute MI begins early but peaks many hours after the onset of injury. The ruptured cells are efficiently cleared by the immune system and are no longer present in the myocardium 72 hours after injury.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.