ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2012
The delayed impact of parental age on offspring mortality in mice.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Parental Age Effects on Offspring Telomere Length Across Vertebrates: A Meta-Analysis.Molecular ecology · 2026Pooled it
- Guidelines for in vivo models of developmental programming of cardiovascular disease risk.American journal of physiology. Heart and circulatory physiology · 2024Review
- The Contributions of Maternal Age Heterogeneity to Variance in Lifetime Reproductive Output.The American naturalist · 2022Article
- The effects of advanced maternal age on T-cell subsets at the maternal-fetal interface prior to term labor and in the offspring: a mouse study.Clinical and experimental immunology · 2020Article
- Parental breeding age effects on descendants' longevity interact over 2 generations in matrilines and patrilines.PLoS biology · 2019Article
- Experimental demonstration that offspring fathered by old males have shorter telomeres and reduced lifespans.Proceedings. Biological sciences · 2018Article
- Developmental Origins of Health Span and Life Span: A Mini-Review.Gerontology · 2018Review
- Pregnancy at Advanced Maternal Age Affects Behavior and Hippocampal Gene Expression in Mouse Offspring.The journals of gerontology. Series A, Biological sciences and medical sciences · 2017Article
- New Developments in the Biodemography of Aging and Longevity.Gerontology · 2015Article
- Aging-induced dysregulation of dicer1-dependent microRNA expression impairs angiogenic capacity of rat cerebromicrovascular endothelial cells.The journals of gerontology. Series A, Biological sciences and medical sciences · 2013Article
- Determinants of exceptional human longevity: new ideas and findings.Vienna yearbook of population research · 2013Article
- Circulating factors induced by caloric restriction in the nonhuman primate Macaca mulatta activate angiogenic processes in endothelial cells.The journals of gerontology. Series A, Biological sciences and medical sciences · 2013Article
- Effects of seasonal, ontogenetic, and genetic factors on lifespan of male and female progeny of Arvicola amphibius.Frontiers in genetics · 2013Article
- Within- and between-species study of extreme longevity--comments, commonalities, and goals.The journals of gerontology. Series A, Biological sciences and medical sciences · 2012Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The certitude of death makes reproduction the foundation upon which all life-history strategies are based. Plasticity in the reproductive biology of organisms is an essential adaptive response to the capricious and hazardous environments of earth. In this article, we use data from a breeding colony for laboratory mice to examine the mortality risks of offspring born at the outer boundaries of their Dam's reproductive plasticity. Our results suggest that the mortality/survival characteristics of offspring are affected by both litter parity and offspring gender. Females born to young Dams have consistently longer life spans than females born to older Dams. Conversely, males are either not affected by parental age or have longer life spans when born to older Dams.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.