ReviewAgents and actions1990
The human eosinophil in inflammation.
Review in Agents and actions, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 46 citations in OpenAlex.
- Therapeutic perspectives on PDE4B inhibition in adipose tissue dysfunction and chronic liver injury.Expert opinion on therapeutic targets · 2024Review
- An in vitro investigation of the anti-inflammatory properties of potassium humate.Inflammation · 2004Article
- A comparison of the inhibitory activity of PDE4 inhibitors on leukocyte PDE4 activity in vitro and eosinophil trafficking in vivo.British journal of pharmacology · 1999Article
- Role of interleukin-5 in enhanced migration of eosinophils from airways of immunized guinea-pigs.British journal of pharmacology · 1994Article
- Effects of phosphodiesterase isoenzyme inhibitors on cutaneous inflammation in the guinea-pig.British journal of pharmacology · 1994Article
- Review
- Characterization and pharmacological modulation of antigen-induced peritonitis in actively sensitized mice.British journal of pharmacology · 1993Article
- Cellular localization of tumor necrosis factor (TNF)-alpha transcripts in normal bowel and in necrotizing enterocolitis. TNF gene expression by Paneth cells, intestinal eosinophils, and macrophages.The American journal of pathology · 1993Article
- Aspergillus antigen-induced eosinophil differentiation in a murine model.Infection and immunity · 1992Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Active research during recent years has clearly shown that the eosinophil is a potent inflammatory cell taking active part in almost all kinds of inflammatory processes. The activity of the human eosinophil is mediated by the secretion of four well characterized cytotoxic proteins, ECP, EPO, EPX/EDN and MBP in addition to lipid mediators such as LTC4 and PAF and toxic oxygen metabolites. The cytotoxic potential of the eosinophil has been demonstrated in a number of diseases with a close association of eosinophil accumulation with secretion of granule proteins and tissue injury. Also the measurements of the proteins in various body fluids have provided evidence for the active participation of eosinophils in a number of diseases such as asthma, ulcerative colitis, rheumatoid arthritis, psoriasis to mention a few. The identification of the principles that attract eosinophils to the sites of inflammation must be a major goal in our attempts to control the activity of this potents cell.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.