ArticleCurrent biology : CB2011
Asymmetry in sexual pheromones is not required for ascomycete mating.
Article in Current biology : CB, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 38 citations in OpenAlex.
- Context-dependent activation and evolutionary buffering of a mating pheromone in fission yeast.Communications biology · 2026Article
- A yeast mating platform for multiplex screening of fungal GPCR-ligand interactions.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Sex Pheromone Receptor Ste2 Orchestrates Chemotropic Growth towards Pine Root Extracts in the Pitch Canker PathogenPathogens (Basel, Switzerland) · 2024Article
- Yeast sexes: mating types do not determine the sexes in Metschnikowia species.FEMS yeast research · 2024Article
- Pheromone Response and Mating Behavior in Fission Yeast.Microbiology and molecular biology reviews : MMBR · 2022Review
- Engineered cell differentiation and sexual reproduction in probiotic and mating yeasts.Nature communications · 2022Article
- Article
- Asymmetric mating behavior of isogamous budding yeast.Science advances · 2021Article
- The evolution of peptide mating pheromones in fission yeast.Current genetics · 2019Review
- Asymmetric diversification of mating pheromones in fission yeast.PLoS biology · 2019Article
- New approaches in bioprocess-control: Consortium guidance by synthetic cell-cell communication based on fungal pheromones.Engineering in life sciences · 2018Review
- Hydrophobin-Based Surface Engineering for Sensitive and Robust Quantification of Yeast Pheromones.Sensors (Basel, Switzerland) · 2016Article
- Article
- Cell biology of yeast zygotes, from genesis to budding.Biochimica et biophysica acta · 2015Review
- Artificial cell-cell communication as an emerging tool in synthetic biology applications.Journal of biological engineering · 2015Article
- Secreting and sensing the same molecule allows cells to achieve versatile social behaviors.Science (New York, N.Y.) · 2014Article
- Article
- Review
- Biogenesis of the Saccharomyces cerevisiae pheromone a-factor, from yeast mating to human disease.Microbiology and molecular biology reviews : MMBR · 2012Review
- Article
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Authors and funding
2 authors at 1 institution in 2 countries.
Funding
Abstract
backgroundWe investigated the determinants of sexual identity in the budding yeast Saccharomyces cerevisiae. The higher fungi are divided into the ascomycetes and the basidiomycetes. Most ascomycetes have two mating types: one (called α in yeasts and MAT1-1 in filamentous fungi) produces a small, unmodified, peptide pheromone, and the other (a in yeasts and MAT1-2 in filamentous fungi) produces a peptide pheromone conjugated to a C-terminal farnesyl group that makes it very hydrophobic. In the basidiomycetes, all pheromones are lipid-modified, and this difference is a distinguishing feature between the phyla. We asked whether the asymmetry in pheromone modification is required for successful mating in ascomycetes.
resultsWe cloned receptor and pheromone genes from a filamentous ascomycete and a basidiomycete and expressed these in the budding yeast, Saccharomyces cerevisiae, to generate novel, alternative mating pairs. We find that two yeast cells can mate even when both cells secrete a-like or α-like peptides. Importantly, this is true regardless of whether the cells express the a- or α-mating-type loci, which control the expression of other, sex-specific genes, in addition to the pheromones and pheromone receptors.
conclusionsWe demonstrate that the asymmetric pheromone modification is not required for successful mating of ascomycete fungi and confirm that, in budding yeast, the primary determinants of mating are the specificity of the receptors and their corresponding pheromones.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.