ArticleCurrent biology : CB2011
An interdependent metabolic patchwork in the nested symbiosis of mealybugs.
Article in Current biology : CB, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 180 papers, 1 of them a synthesis that pooled it.
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180 citing papers in PubMed, 1 synthesis or guideline pooled it, 380 citations in OpenAlex.
- Identification of robust and generalizable biomarkers for microbiome-based stratification in lifestyle interventions.Microbiome · 2023Pooled it
- Stability in flexibility: Shifting alliances stabilize the symbioses of marine animals over 150 million years.Science advances · 2026Article
- Coevolution of Codependent Hosts and Symbionts.bioRxiv : the preprint server for biology · 2026Article
- Evolutionary signals in metabolic networks of insect endosymbionts revealed through comparative topological modeling.BMC genomics · 2026Article
- Cellular remodeling of ovarian follicular epithelial cells transmits an obligate nutritional endosymbiont in a scale insect.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Fidelity in co-diversified symbiosis.Nature communications · 2026Article
- Genome degradation results in nested symbiosis and endosymbiont replacement in cicadas.Nature communications · 2025Article
- The Endosymbiont Consortia of Two Cixiidae Planthoppers Reveal an Ancient Symbiosis With 'Candidatus Mirabilia Symbiotica'.Environmental microbiology reports · 2025Article
- Targeted disruption of theiScience · 2025Article
- Characterization of bacterial diversity associated with a Salar de Atacama native plant Nitrophila atacamensis.Environmental microbiome · 2025Article
- An obligate symbiont ofApplied and environmental microbiology · 2025Article
- Protein import into bacterial endosymbionts and evolving organelles.The FEBS journal · 2025Review
- Distinct bacteria display genus and species-specific associations with mycobionts in paramo lichens in Colombia.FEMS microbiology ecology · 2025Article
- Facultatively intrabacterial localization of a planthopper endosymbiont as an adaptation to its vertical transmission.mSystems · 2024Article
- Twenty-nine newly sequenced genomes and a comprehensive genome dataset for the insect endosymbiont Buchnera.Scientific data · 2024Article
- Extreme specificity in obligate mutualism-A role for competition?Ecology and evolution · 2024Article
- PacBio Hi-Fi genome assembly of Sipha maydis, a model for the study of multipartite mutualism in insects.Scientific data · 2024Article
- Article
- Retention of an Endosymbiont for the Production of a Single Molecule.Genome biology and evolution · 2024Article
- Endosymbiont Tremblaya phenacola influences the reproduction of cotton mealybugs by regulating the mechanistic target of rapamycin pathway.The ISME journal · 2024Article
120 more citing papers are in PubMed but not listed here.
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2 authors at 2 institutions in 1 country.
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Abstract
Highly reduced genomes of 144-416 kilobases have been described from nutrient-provisioning bacterial symbionts of several insect lineages [1-5]. Some host insects have formed stable associations with pairs of bacterial symbionts that live in specialized cells and provide them with essential nutrients; genomic data from these systems have revealed remarkable levels of metabolic complementarity between the symbiont pairs [3, 4, 6, 7]. The mealybug Planococcus citri (Hemiptera: Pseudococcidae) contains dual bacterial symbionts existing with an unprecedented organization: an unnamed gammaproteobacteria, for which we propose the name Candidatus Moranella endobia, lives inside the betaproteobacteria Candidatus Tremblaya princeps [8]. Here we describe the complete genomes and metabolic contributions of these unusual nested symbionts. We show that whereas there is little overlap in retained genes involved in nutrient production between symbionts, several essential amino acid pathways in the mealybug assemblage require a patchwork of interspersed gene products from Tremblaya, Moranella, and possibly P. citri. Furthermore, although Tremblaya has the smallest cellular genome yet described, it contains a genomic inversion present in both orientations in individual insects, starkly contrasting with the extreme structural stability typical of highly reduced bacterial genomes [4, 9, 10].
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.