ReviewEuropean neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology2011
Circadian rhythms and mood regulation: insights from pre-clinical models.
Review in European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
71 citing papers in PubMed, 1 synthesis or guideline pooled it, 170 citations in OpenAlex.
- High circadian stimulus lighting therapy for depression: Meta-analysis of clinical trials.Frontiers in neuroscience · 2022Pooled it
- Seasonal and Time-of-Day Variations in Ambulance-Transported Emergency Department Diagnoses: A One-Year Observational Study.Healthcare (Basel, Switzerland) · 2026Article
- Sleep Quality and Mental Health of High-Level Esports Competitors: A Cross-Sectional Study.Healthcare (Basel, Switzerland) · 2026Article
- Digital Monitoring of Micro- and Macro-Movement Regularity in Psychiatric Inpatients With Depression.Psychiatry investigation · 2026Article
- Mindfulness exercise and mental health among university students: the sequential mediating roles of sleep regularity and self-control.Frontiers in psychology · 2026Article
- Light therapy for bipolar disorders: Clinical recommendations from the international society for bipolar disorders (ISBD) Chronobiology and Chronotherapy Task Force.Dialogues in clinical neuroscience · 2025Review
- Subcortical functional connectivity alterations in first-episode medication-naïve adolescents with major depressive disorder.European child & adolescent psychiatry · 2025Article
- Evaluation of seasonal variations for the seasonal pattern assessment in mood disorder patients and healthy controls.BMC psychiatry · 2025Article
- A translationally informed approach to vital signs for psychiatry: a preliminary proof of concept.NPP - digital psychiatry and neuroscience · 2024Article
- Clinical guidelines for the use of lifestyle-based mental health care in major depressive disorder: World Federation of Societies for Biological Psychiatry (WFSBP) and Australasian Society of Lifestyle Medicine (ASLM) taskforce.The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry · 2023Article
- Can melatonin reduce the severity of post-COVID-19 syndrome?EXCLI journal · 2023Review
- Multi-Level Processes and Retina-Brain Pathways of Photic Regulation of Mood.Journal of clinical medicine · 2022Review
- The cumulative effect of chronic stress and depressive symptoms affects heart rate in a working population.Frontiers in psychiatry · 2022Article
- Twitter, time and emotions.Royal Society open science · 2021Article
- The effect of melatonin on quality of sleep in patients with sleep disturbance admitted to post coronary care units: A randomized controlled trial.BioMedicine · 2021Article
- Disrupted circadian rhythms and mental health.Handbook of clinical neurology · 2021Review
- Characterizing Behavioral Activity Rhythms in Older Adults Using Actigraphy.Sensors (Basel, Switzerland) · 2020Review
- Regulation of Circadian Genes by the MAPK Pathway: Implications for Rapid Antidepressant Action.Neuroscience bulletin · 2020Review
- Mood-related central and peripheral clocks.The European journal of neuroscience · 2020Review
- Mitochondria, Metabolism, and Redox Mechanisms in Psychiatric Disorders.Antioxidants & redox signaling · 2019Review
11 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Affective disorders such as major depression, bipolar disorder, and seasonal affective disorder are associated with major disruptions in circadian rhythms. Indeed, altered sleep/wake cycles are a critical feature for diagnosis in the DSM IV and several of the therapies used to treat these disorders have profound effects on rhythm length and stabilization in human populations. Furthermore, multiple human genetic studies have identified polymorphisms in specific circadian genes associated with these disorders. Thus, there appears to be a strong association between the circadian system and mood regulation, although the mechanisms that underlie this association are unclear. Recently, a number of studies in animal models have begun to shed light on the complex interactions between circadian genes and mood-related neurotransmitter systems, the effects of light manipulation on brain circuitry, the impact of chronic stress on rhythms, and the ways in which antidepressant and mood-stabilizing drugs alter the clock. This review will focus on the recent advances that have been gleaned from the use of pre-clinical models to further our understanding of how the circadian system regulates mood.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.