Evidence map›Paper›PMID 21835591›Full record

ArticleJournal of clinical epidemiology2012

Health burden in chronic disease: multimorbidity is associated with self-rated health more than medical comorbidity alone.

Anthony V Perruccio, Jeffrey N Katz, Elena Losina

Abstract read
In one paragraph

Article in Journal of clinical epidemiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

56 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Self-Rated Health as a Predictor of Mortality in Older Adults: A Systematic Review.International journal of environmental research and public health · 2023
    Pooled it
  3. Trial
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  7. Perceived neighborhood disadvantage and poor chronic health in Israel.Israel journal of health policy research · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Anthony V PerruccioBrigham and Women's Hospital, Boston, MA, USA. perrucci@uhnres.utoronto.ca
Jeffrey N Katz
Elena Losina

Funding

Trial of risk mangement for prevention of accelerated atherosclerosis in SLEP60AR047782 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI LOSINA, ELENA · 2001 to 2016
$18.8M
Patient Oriented Research and Mentoring Program in OrthopedicsK24AR057827 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI LOSINA, ELENA · 2010 to 2019
$1.7M
Musculoskeletal Research and Mentoring ProgramsK24AR002123 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI KATZ, JEFFREY NEIL · 2000 to 2009
$1.1M
CIHR SBM 90860NIAMS NIH HHS K24 AR002123NIAMS NIH HHS K24 AR 02123NIAMS NIH HHS K24 AR 057827NIAMS NIH HHS K24 AR057827NIAMS NIH HHS P60 AR047782NIAMS NIH HHS P60 AR 47782
6 · The paper itself

Abstract

objectivesTo investigate the association between multimorbidity-a construct comprising several health domains (medical comorbidity, musculoskeletal, physical and social functional status, mental health, and geriatric problems)-and overall self-rated health (SRH), an important chronic disease health outcome. We investigate whether medical comorbidity effects are mediated through other health domains and whether these domains have independent effects on SRH. STUDY DESIGN AND

settingMedicare recipients (n=958) completed a questionnaire 3 years post primary total hip replacement surgery. Self-reported sociodemographic characteristics, SRH, and health domain statuses were ascertained. Probit regressions and path analyses were used to evaluate the independent effects of the health domains on SRH and the interrelationships between domains and to quantify direct and mediated effects.

resultsAll domains were independently associated with SRH. Medical comorbidity explained 11.7% of the variance in SRH, and all other health domains explained 27.3%. The impact of medical comorbidity was largely direct (only 21.5% mediated through other domains). Medical comorbidity minimally explained the variance in other domain scores.

conclusionSRH has multiple determinants. This finding suggests that an exclusive focus on any one domain in health research may limit the researchers' ability to understand health outcomes for which SRH is predictive.

Indexed as

Arthroplasty, Replacement, HipChronic DiseaseComorbidityCost of IllnessHealth StatusSelf ReportHumansMedicareOsteoarthritisSurveys and QuestionnairesUnited States

Identifiers

PMID21835591
PMCPMC3217092

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.