ArticleNeuron2011
Endocannabinoids gate state-dependent plasticity of synaptic inhibition in feeding circuits.
Article in Neuron, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 65 citations in OpenAlex.
- The Endocannabinoid System in the Development and Treatment of Obesity: Searching for New Ideas.International journal of molecular sciences · 2025Review
- Overabundant endocannabinoids in neurons are detrimental to cognitive function.bioRxiv : the preprint server for biology · 2024Article
- Endogenous cannabinoids in the piriform cortex tune olfactory perception.Nature communications · 2024Article
- Serotonergic Modulation of the Excitation/Inhibition Balance in the Visual Cortex.International journal of molecular sciences · 2023Article
- 2-AG-Mediated Control of GABAergic Signaling Is Impaired in a Model of Epilepsy.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Brain is modulated by neuronal plasticity during postnatal development.The journal of physiological sciences : JPS · 2021Review
- The ins and outs of inhibitory synaptic plasticity: Neuron types, molecular mechanisms and functional roles.The European journal of neuroscience · 2021Review
- Article
- CB1 cannabinoid receptor-mediated plasticity of GABAergic synapses in the mouse insular cortex.Scientific reports · 2020Article
- Heterosynaptic Plasticity in Cortical Interneurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- A novel GPR55-mediated satiety signal in the oval Bed Nucleus of the Stria Terminalis.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Article
- Cholecystokinin Switches the Plasticity of GABA Synapses in the Dorsomedial Hypothalamus via Astrocytic ATP Release.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Endocannabinoid signaling in hypothalamic circuits regulates arousal from general anesthesia in mice.The Journal of clinical investigation · 2017Article
- Nutritional status-dependent endocannabinoid signalling regulates the integration of rat visceral information.The Journal of physiology · 2017Article
- Morphine-induced synaptic plasticity in the VTA is reversed by HDAC inhibition.Journal of neurophysiology · 2016Article
- The endocannabinoid system in guarding against fear, anxiety and stress.Nature reviews. Neuroscience · 2015Review
- Postsynaptic Depolarization Enhances GABA Drive to Dorsomedial Hypothalamic Neurons through Somatodendritic Cholecystokinin Release.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Microglia-dependent alteration of glutamatergic synaptic transmission and plasticity in the hippocampus during peripheral inflammation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- New horizons on the role of cannabinoid CB1 receptors in palatable food intake, obesity and related dysmetabolism.International journal of obesity supplements · 2014Review
- Non-associative potentiation of perisomatic inhibition alters the temporal coding of neocortical layer 5 pyramidal neurons.PLoS biology · 2014Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Changes in food availability alter the output of hypothalamic nuclei that underlie energy homeostasis. Here, we asked whether food deprivation impacts the ability of GABA synapses in the dorsomedial hypothalamus (DMH), an important integrator of satiety signals, to undergo activity-dependent changes. GABA synapses in DMH slices from satiated rats exhibit endocannabinoid-mediated long-term depression (LTD(GABA)) in response to high-frequency stimulation of afferents. When CB1Rs are blocked, however, the same stimulation elicits long-term potentiation (LTP(GABA)), which manifests presynaptically and requires heterosynaptic recruitment of NMDARs and nitric oxide (NO). Interestingly, NO signaling is required for eCB-mediated LTD(GABA). Twenty-four hour food deprivation results in a CORT-mediated loss of CB1R signaling and, consequently, GABA synapses only exhibit LTP(GABA). These observations indicate that CB1R signaling promotes LTD(GABA) and gates LTP(GABA). Furthermore, the satiety state of an animal, through regulation of eCB signaling, determines the polarity of activity-dependent plasticity at GABA synapses in the DMH.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.