Evidence map›Paper›PMID 21835336›Full record

ArticleNeuron2011

The battle over inhibitory synaptic plasticity in satiety brain circuits.

Thomas J Younts, Pablo E Castillo

Abstract readComment
In one paragraph

Article in Neuron, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Thomas J YountsDominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Pablo E Castillo

Funding

Presynaptic Forms of Long-Term Plasticity in the CNSR01DA017392 · NIDA · YESHIVA UNIVERSITY · PI CASTILLO, PABLO E · 2003 to 2019
$4.5M
Activity-dependent synaptic plasticity expressed by NMDARsR01MH081935 · NIMH · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI CASTILLO, PABLO E · 2008 to 2018
$4.0M
NIDA NIH HHS R01 DA017392NIMH NIH HHS R01 MH081935
6 · The paper itself

Abstract

The synaptic basis underlying food intake is poorly understood. New research shows that an animal's satiety state dictates the polarity of long-term inhibitory synaptic plasticity in the hypothalamus, which is mediated by an activity-dependent competition between endocannabinoid and nitric oxide signaling.

Identifiers

PMID21835336
PMCPMC3163478

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.