Trial reportJournal of neuroscience methods2011
Spatial and orientational heterogeneity in the statistical sensitivity of skeleton-based analyses of diffusion tensor MR imaging data.
Trial report in Journal of neuroscience methods, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Imaging Alzheimer's genetic risk using diffusion MRI: A systematic review.NeuroImage. Clinical · 2020Pooled it
- Working memory training and brain structure and function in extremely preterm or extremely low birth weight children.Human brain mapping · 2020Trial
- White matter hyperintensities in cholinergic pathways correlates of cognitive impairment in moyamoya disease.European radiology · 2024Article
- Diffusion MRI with Machine Learning.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Glymphatic System Activity and Brain Morphology in Patients With Psychogenic Non-epileptic Seizures.Cureus · 2024Article
- Elevated Systemic Inflammation Is Associated with Reduced Corticolimbic White Matter Integrity in Depression.Life (Basel, Switzerland) · 2021Article
- White Matter Changes With Rehabilitation in Children With Developmental Coordination Disorder: A Randomized Controlled Trial.Frontiers in human neuroscience · 2021Article
- White matter microstructure correlates with mathematics but not word reading performance in 13-year-old children born very preterm and full-term.NeuroImage. Clinical · 2019Article
- Characterisation of brain volume and microstructure at term-equivalent age in infants born across the gestational age spectrum.NeuroImage. Clinical · 2019Article
- Observational
- Compressed Sensing Diffusion Spectrum Imaging for Accelerated Diffusion Microstructure MRI in Long-Term Population Imaging.Frontiers in neuroscience · 2018Article
- White matter microstructure is associated with language in children born very preterm.NeuroImage. Clinical · 2018Article
- Diffusion Tensor Imaging (DTI) Correlates of Self-Reported Sleep Quality and Depression Following Mild Traumatic Brain Injury.Frontiers in neurology · 2018Article
- Article
- White Matter Diffusion of Major Fiber Tracts Implicated in Autism Spectrum Disorder.Brain connectivity · 2016Article
- Axon density and axon orientation dispersion in children born preterm.Human brain mapping · 2016Article
- Sexual dimorphic abnormalities in white matter geometry common to schizophrenia and non-psychotic high-risk subjects: Evidence for a neurodevelopmental risk marker?Human brain mapping · 2016Article
- Article
- Region of interest correction factors improve reliability of diffusion imaging measures within and across scanners and field strengths.NeuroImage · 2015Article
- Connectivity-based fixel enhancement: Whole-brain statistical analysis of diffusion MRI measures in the presence of crossing fibres.NeuroImage · 2015Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Group comparisons of indices derived from diffusion tensor imaging are common in the literature. An increasingly popular approach to performing such comparisons is the skeleton-projection based approach where, for example, fractional anisotropy (FA) values are projected onto a skeletonized version of the data to minimize differences due to spatial misalignment. In this work, we examine the spatial heterogeneity of the statistical power to detect group differences, and show that there is an intrinsic spatial heterogeneity, with more 'central' structures having less variance within a population. Importantly, we also demonstrate a previously unreported feature of skeleton-based analysis methods, that is that the width of the skeleton depends on the relative orientation to the imaging matrix. Due to the way in which the inferential statistics are performed, this means that structures that are obliquely oriented to the imaging matrix are more likely to show significant differences than when aligned with the imaging matrix. This has profound implications for the interpretation of results obtained from such analysis, especially when there are no a priori hypotheses concerning the spatial location of any group differences. For a uniform (DC) offset between two groups, the skeleton projection-based approaches will be most likely to reveal a difference in centrally located white matter structures oriented obliquely to the imaging matrix.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.