ArticleAnalytical chemistry2011
Isothermal discrimination of single-nucleotide polymorphisms via real-time kinetic desorption and label-free detection of DNA using silicon photonic microring resonator arrays.
Article in Analytical chemistry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed.
- Biofunctionalization of Multiplexed Silicon Photonic Biosensors.Biosensors · 2022Review
- Surface Plasmon Resonance (SPR) Spectroscopy and Photonic Integrated Circuit (PIC) Biosensors: A Comparative Review.Sensors (Basel, Switzerland) · 2022Review
- Whispering-Gallery Sensors.Matter · 2020Review
- Silicon Photonic Biosensors Using Label-Free Detection.Sensors (Basel, Switzerland) · 2018Review
- Multiplexed microRNA Expression Profiling by Combined Asymmetric PCR and Label-Free Detection using Silicon Photonic Sensor Arrays.Analytical methods : advancing methods and applications · 2018Article
- A Guide to Quantitative Biomarker Assay Development using Whispering Gallery Mode Biosensors.Current protocols in chemical biology · 2017Article
- PCR-Free, Multiplexed Expression Profiling of microRNAs Using Silicon Photonic Microring Resonators.Analytical chemistry · 2016Article
- Applications of Optical Microcavity Resonators in Analytical Chemistry.Annual review of analytical chemistry (Palo Alto, Calif.) · 2016Article
- Whispering gallery mode sensors.Advances in optics and photonics · 2015Article
- On-chip detection of a single nucleotide polymorphism without polymerase amplification.Nano research · 2014Article
- Ultraspecific and highly sensitive nucleic acid detection by integrating a DNA catalytic network with a label-free microcavity.Small (Weinheim an der Bergstrasse, Germany) · 2014Article
- Biomolecular analysis with microring resonators: applications in multiplexed diagnostics and interaction screening.Current opinion in chemical biology · 2013Review
- Interfacing lipid bilayer nanodiscs and silicon photonic sensor arrays for multiplexed protein-lipid and protein-membrane protein interaction screening.Analytical chemistry · 2013Article
- Label-free detection with high-Q microcavities: a review of biosensing mechanisms for integrated devices.Nanophotonics (Berlin, Germany) · 2012Article
- Chaperone probes and bead-based enhancement to improve the direct detection of mRNA using silicon photonic sensor arrays.Analytical chemistry · 2012Article
- High-Q optical sensors for chemical and biological analysis.Analytical chemistry · 2012Review
- Rapid, multiparameter profiling of cellular secretion using silicon photonic microring resonator arrays.Journal of the American Chemical Society · 2011Article
- Label-free, multiplexed detection of bacterial tmRNA using silicon photonic microring resonators.Biosensors & bioelectronicsArticle
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
We report a sensitive, label-free method for detecting single-stranded DNA and discriminating between single nucleotide polymorphisms (SNPs) using arrays of silicon photonic microring resonators. In only a 10 min assay, DNA is detected at subpicomole levels with a dynamic range of 3 orders of magnitude. Following quantitation, sequence discrimination with single nucleotide resolution is achieved isothermally by monitoring the dissociation kinetics of the duplex in real-time using an array of SNP-specific capture probes. By leveraging the capabilities of the microring resonator platform, we successfully generate multiplexed arrays to quickly screen for the presence and identity of SNPs and show the robustness of this methodology by analyzing multiple target sequences of varying GC content. Furthermore, we show that this technique can be used to distinguish both homozygote and heterozygote alleles.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.