Evidence map›Paper›PMID 21834504›Full record

ArticleOrganic letters2011

Multicomponent assembly strategies for the synthesis of diverse tetrahydroisoquinoline scaffolds.

Brett A Granger, Kyosuke Kaneda, Stephen F Martin

Abstract read
In one paragraph

Article in Organic letters, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Allosteric GABAMolecules (Basel, Switzerland) · 2020
    Review
  6. Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Brett A GrangerDepartment of Chemistry and Biochemistry, The Texas Institute for Drug and Diagnostic Development, The University of Texas at Austin, Austin, Texas 78712, USA.
Kyosuke Kaneda
Stephen F Martin

Funding

SYNTHESIS OF NITROGEN-CONTAINING NATURAL PRODUCTSR01GM025439 · NIGMS · UNIVERSITY OF TEXAS AUSTIN · PI MARTIN, STEPHEN · 1985 to 2010
$2.4M
Generating Diverse Pilot-Scale Libraries for ScreeningP41GM086192 · NIGMS · UNIVERSITY OF TEXAS AT AUSTIN · PI MARTIN, STEPHEN · 2008 to 2010
$1.1M
NIGMS NIH HHS GM 24539NIGMS NIH HHS GM 86192NIGMS NIH HHS P41 GM086192NIGMS NIH HHS R01 GM025439
6 · The paper itself

Abstract

Several novel multicomponent assembly processes have been developed for the rapid and efficient assembly of various heterocyclic scaffolds bearing a tetrahydroisoquinoline core, each of which allows for facile derivatization to access a diverse array of compounds. This work led to the serendipitous discovery of a new method for the synthesis of a fused quinazolone ring system, which was applied to a one-step total synthesis of the quinazolinocarboline alkaloid rutaecarpine.

Indexed as

Molecular StructureStereoisomerismTetrahydroisoquinolinesTetrahydroisoquinolines

Identifiers

PMID21834504
PMCPMC3164803

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.