ArticleAge (Dordrecht, Netherlands)2012
Handgrip strength at midlife and familial longevity : The Leiden Longevity Study.
Article in Age (Dordrecht, Netherlands), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Population-specific equations of age-related maximum handgrip force: a comprehensive review.PeerJ · 2024Pooled it
- A Grand Challenge in Aging Interventions: From Mice to Humans.Frontiers in aging · 2020Article
- Association of Family History of Exceptional Longevity With Decline in Physical Function in Aging.The journals of gerontology. Series A, Biological sciences and medical sciences · 2017Article
- Precipitous Dehydroepiandrosterone Declines Reflect Decreased Physical Vitality and Function.The journals of gerontology. Series A, Biological sciences and medical sciences · 2017Article
- The Survival of Spouses Marrying Into Longevity-Enriched Families.The journals of gerontology. Series A, Biological sciences and medical sciences · 2017Article
- Handgrip strength, ageing and mortality in rural Africa.Age and ageing · 2015Article
- Accelerating aging research: how can we measure the rate of biologic aging?Experimental gerontology · 2015Article
- [Successful aging and indicators of frailty in the elderly. Octabaix Study].Atencion primaria · 2014Article
- Biological age and tempos of aging in women over 60 in connection with their morphofunctional characteristics.Journal of physiological anthropology · 2014Article
- Defining sarcopenia: the impact of different diagnostic criteria on the prevalence of sarcopenia in a large middle aged cohort.Age (Dordrecht, Netherlands) · 2013Article
- Identifying the genomic determinants of aging and longevity in human population studies: progress and challenges.BioEssays : news and reviews in molecular, cellular and developmental biology · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Low handgrip strength has been linked with premature mortality in diverse samples of middle-aged and elderly subjects. The value of handgrip strength as marker of "exceptional" human longevity has not been previously explored. We postulated that the genetic influence on extreme survival might also be involved in the muscular strength determination pathway. Therefore, the objective of this study was to assess the muscle strength in a sample of middle-aged adults who are genetically enriched for exceptional survival and comparing them to a control group. We included 336 offspring of the nonagenarian from the Leiden Longevity Study who were enriched for heritable exceptional longevity, and 336 of their partners were used as controls. The Leiden Longevity study was a prospective follow up study of long-living siblings pairs together with their offspring and their partners. Handgrip strength was used as a proxy for overall muscle strength. No significant difference in handgrip strength was seen between the offspring of the nonagenarian and their partners after adjustment for potential confounders including body compositions, sum score of comorbidities, medication use, smoking and alcohol history. The main determinants of midlife handgrip strength were age, gender, total body percentage fat and relative appendicular lean mass. Although midlife handgrip strength has previously been shown to be an important prognostic indicator of survival, it is not a marker of exceptional familial longevity in middle-aged adults. This finding suggests that genetic component of susceptibility to extreme survival is likely to be separate from that of muscular strength.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.