ArticleCurrent genetics2011
A putative ABC transporter gene, ZRA1, is required for zearalenone production in Gibberella zeae.
Article in Current genetics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 46 citations in OpenAlex.
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- Dimethyl Sulfoxide Suppresses Fusarium graminearum Pathogenicity by Modulating Key Life Cycle Traits.The plant pathology journal · 2025Article
- A putative ABC transporter gene,Microbiology spectrum · 2025Article
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- Effects of β-estradiol on the Phytopathogenic Fungus Fusarium graminearum.The plant pathology journal · 2025Article
- Zearalenone contamination in maize, its associated producing fungi, control strategies, and legislation in Sub-Saharan Africa.Food science & nutrition · 2024Review
- Metabolomic Analysis of Extracellular Vesicles from the Cereal Fungal PathogenJournal of fungi (Basel, Switzerland) · 2023Article
- Aggressiveness and Patulin Production inPlants (Basel, Switzerland) · 2023Article
- Genomic insights intoFrontiers in microbiology · 2023Article
- Antagonistic effects ofFrontiers in microbiology · 2023Article
- Effect of Compactin on the Mycotoxin Production and Expression of Related Biosynthetic and Regulatory Genes in ToxigenicMicroorganisms · 2022Article
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- The ORF2 protein of Fusarium graminearum virus 1 suppresses the transcription of FgDICER2 and FgAGO1 to limit host antiviral defences.Molecular plant pathology · 2020Article
- Transcriptome analyses of the ginseng root rot pathogensJournal of ginseng research · 2020Article
- Article
- Engineering of the Filamentous FungusFrontiers in microbiology · 2018Review
- Translating biosynthetic gene clusters into fungal armor and weaponry.Nature chemical biology · 2015Review
- Co-ordination between BrlA regulation and secretion of the oxidoreductase FmqD directs selective accumulation of fumiquinazoline C to conidial tissues in Aspergillus fumigatus.Cellular microbiology · 2014Article
- Next-generation sequencing approach for connecting secondary metabolites to biosynthetic gene clusters in fungi.Frontiers in microbiology · 2014Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Zearalenone (ZEA) is a secondary metabolite produced by various Fusarium species and causes estrogenic disorders in humans and animals. Recent studies have identified the ZEA biosynthesis gene cluster in F. graminearum, but other genes such as transporters responsible for ZEA export have not been identified in the cluster. In this study, we performed microarray analyses from the wild-type strain with and without ZEA supplementation and ZEA-nonproducing strain zeb2 to discover other genes responsible for ZEA biosynthesis. Three putative ABC transporters were significantly down-regulated in the zeb2 and were under positive regulation of the ZEB2 gene, which functions as a transcriptional activator for ZEA production in this fungus. However, only one gene (ZRA1) was found to be up-regulated by 20-fold in the wild-type strain supplemented with ZEA, and deletion of ZRA1 resulted in reduced ZEA production. Deletions of the other two genes showed similar ZEA productions as the wild-type strain. ZRA1 localized to the plasma membrane and vacuoles indicating possible roles of ZRA1 as a transporter. This study indicated that ZRA1 is involved in ZEA production and shares a common regulatory mode with ZEA cluster genes by ZEB2.
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