ReviewCurrent rheumatology reports2011
Evidence for shared pain mechanisms in osteoarthritis, low back pain, and fibromyalgia.
Review in Current rheumatology reports, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02246088 (Effect of Neuroscience Education on Subjects With Chronic Knee Pain Related to Osteoarthritis), which is not on this map. Cited by 82 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Neuroscience Education on Subjects With Chronic Knee Pain Related to Osteoarthritis : a Randomized Controlled Trial
Who cites it
82 citing papers in PubMed, 4 syntheses or guidelines pooled it, 173 citations in OpenAlex.
- Effectiveness of Movement Representation Techniques in Chronic Non-Specific Spinal Pain: A Systematic Review and Meta-Analysis.Medicina (Kaunas, Lithuania) · 2026Pooled it
- Role of non-invasive objective markers for the rehabilitative diagnosis of central sensitization in patients with fibromyalgia: A systematic review.Journal of back and musculoskeletal rehabilitation · 2024Pooled it
- Effects of Different Trunk Training Methods for Chronic Low Back Pain: A Meta-Analysis.International journal of environmental research and public health · 2022Pooled it
- Variations in patient-reported physical health between cardiac and musculoskeletal diseases: systematic review and meta-analysis of population-based studies.Health and quality of life outcomes · 2015Pooled it
- Paraspinous Lidocaine Injection for Chronic Nonspecific Low Back Pain: A Randomized Controlled Clinical Trial.The journal of pain · 2016Trial
- Pain sensitivity subgroups in individuals with spine pain: potential relevance to short-term clinical outcome.Physical therapy · 2014Trial
- Spinal manipulative therapy-specific changes in pain sensitivity in individuals with low back pain (NCT01168999).The journal of pain · 2014Trial
- Effects of the carrier frequency of interferential current on pain modulation in patients with chronic nonspecific low back pain: a protocol of a randomised controlled trial.BMC musculoskeletal disorders · 2013Trial
- Fibromyalgia: A Multifactorial Pain Disorder.International journal of molecular sciences · 2026Review
- Performance-Based and Self-Reported Frailty in Older Adults with or Without Fibromyalgia.European journal of investigation in health, psychology and education · 2026Article
- Does the predominance of central sensitization alter the effect of balneotherapy combined with conventional physical therapy in patients with chronic low back and knee pain?International journal of biometeorology · 2026Observational
- Comparing physical activity practice, pain and psychological characteristics in individuals with fibromyalgia and individuals with low back pain.Chiropractic & manual therapies · 2026Article
- Assessment of central pain sensitization in chronic low back pain and its utility in diagnosis and prediction of clinical severity.Scientific reports · 2026Article
- Genomic structural equation modeling decodes skeletal aging: novel loci discovery and multisystem genetic crosstalk.Journal of translational medicine · 2025Article
- Mu-opioid receptor expression on B cells as a potential biomarker for chronic pain: a follow-up study with patients with fibromyalgia.Pain reports · 2025Article
- Stellate Ganglion Block for PTSD and Chronic Low Back Pain: A Case Report of Three Veterans.Journal of clinical medicine · 2025Article
- Diffuse Noxious Inhibitory Controls in Chronic Pain States: Insights from Pre-Clinical Studies.International journal of molecular sciences · 2025Review
- About Distress in Chronic Pain Conditions: A Pre-Post Study on the Effectiveness of a Mindfulness-Based Intervention for Fibromyalgia and Low Back Pain Patients.International journal of environmental research and public health · 2024Article
- What are the functional and clinical characteristics shared by fibromyalgia and low back pain? A scoping review.BMC rheumatology · 2024Article
- Differences in self-reported signs related to central sensitization and pressure pain threshold related to knee osteoarthritis and sarcopenia.European geriatric medicine · 2024Article
22 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Osteoarthritis (OA), low back pain (LBP), and fibromyalgia (FM) are common chronic pain disorders that occur frequently in the general population. They are a significant cause of dysfunction and disability. Why some of these chronic pain disorders remain localized to few body areas (OA and LBP), whereas others become widespread (FM) is unclear at this time. Genetic, environmental, and psychosocial factors likely play an important role. Although patients with OA, LBP, and FM frequently demonstrate abnormalities of muscles, ligaments, or joints, the severity of such changes is only poorly correlated with clinical pain. Importantly, many patients with these chronic pain disorders show signs of central sensitization and abnormal endogenous pain modulation. Nociceptive signaling is actively regulated by the central nervous system to allow adaptive responses after tissue injuries. Thus, abnormal processing of tonic peripheral tissue impulse input likely plays an important role in the pathogenesis of OA, LBP, or FM. Tonic and/or intense afferent nociceptive barrage can result in central sensitization that depends on facilitatory input from brainstem centers via descending pain pathways to the spinal cord. Abnormal endogenous control of these descending pathways can lead to excessive excitability of dorsal horn neurons of the spinal cord and pain. Ineffective endogenous pain control and central sensitization are important features of OA, LBP, and FM patients.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.