ArticleAnnals of biomedical engineering2011
Transient supplementation of anabolic growth factors rapidly stimulates matrix synthesis in engineered cartilage.
Article in Annals of biomedical engineering, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 44 citations in OpenAlex.
- Article
- Article
- A Novel EphA4 Signaling-Based Therapeutic Strategy for Osteoarthritis in Mice.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2022Article
- Design and fabrication of a hybrid alginate hydrogel/poly(ε-caprolactone) mold for auricular cartilage reconstruction.Journal of biomedical materials research. Part B, Applied biomaterials · 2019Article
- Near-Infrared Spectroscopy Predicts Compositional and Mechanical Properties of Hyaluronic Acid-Based Engineered Cartilage Constructs.Tissue engineering. Part A · 2018Article
- Article
- Scaffold-free approach produces neocartilage tissue of similar quality as the use of HyStem™ and Hydromatrix™ scaffolds.Journal of materials science. Materials in medicine · 2017Article
- Cartilage-Specific Knockout of the Mechanosensory Ion Channel TRPV4 Decreases Age-Related Osteoarthritis.Scientific reports · 2016Article
- Effects of Mesenchymal Stem Cell and Growth Factor Delivery on Cartilage Repair in a Mini-Pig Model.Cartilage · 2016Article
- Long-term storage and preservation of tissue engineered articular cartilage.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2016Article
- Effects of Chondroitinase ABC-Mediated Proteoglycan Digestion on Decellularization and Recellularization of Articular Cartilage.PloS one · 2016Article
- Heterogeneous engineered cartilage growth results from gradients of media-supplemented active TGF-β and is ameliorated by the alternative supplementation of latent TGF-β.Biomaterials · 2016Article
- Biocompatibility of polysebacic anhydride microparticles with chondrocytes in engineered cartilage.Colloids and surfaces. B, Biointerfaces · 2015Article
- Porous titanium bases for osteochondral tissue engineering.Acta biomaterialia · 2015Article
- Cartilage repair and subchondral bone remodeling in response to focal lesions in a mini-pig model: implications for tissue engineering.Tissue engineering. Part A · 2015Article
- A high throughput mechanical screening device for cartilage tissue engineering.Journal of biomechanics · 2014Article
- Maximizing cartilage formation and integration via a trajectory-based tissue engineering approach.Biomaterials · 2014Article
- Growth factor stimulation improves the structure and properties of scaffold-free engineered auricular cartilage constructs.PloS one · 2014Article
- TGF-β3-induced chondrogenesis in co-cultures of chondrocytes and mesenchymal stem cells on biodegradable scaffolds.Biomaterials · 2014Article
- Three-dimensional scaffold-free fusion culture: the way to enhance chondrogenesis of in vitro propagated human articular chondrocytes.European journal of histochemistry : EJH · 2013Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
The purpose of the presented work is to examine the response of engineered cartilage to a transient, 2-week application of anabolic growth factors compared to continuous exposure in in vitro culture. Immature bovine chondrocytes were suspended in agarose hydrogel and cultured for 28 days (Study 1) or 42 days (Study 2) in chondrogenic media with TGF-β1, TGF-β3, or IGF-I either added for only the first 14 days in culture or added to the media for the entire study period. In both studies, there were no statistical differences in tissue mechanical or biochemical properties between the growth factors on day 14. In Study 1, growth factor removal led to a significant and drastic increase in Young's modulus and glycosaminoglycans content compared to continuously exposed controls on day 28. In Study 2, both TGF-β1 and β3 led to significantly higher mechanical properties and collagen content vs. IGF-I on day 42. These results indicate that the rapid rise in tissue properties (previously observed with TGF-β3 only) is not dependent on the type but rather the temporal application of the anabolic growth factor. These findings shed light on possible techniques to rapidly develop engineered cartilage tissue for the future treatment of osteoarthritis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.