ArticleWiener klinische Wochenschrift2011
Homocysteine and asymmetric dimethylarginine in relation to B vitamins in elderly people.
Article in Wiener klinische Wochenschrift, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 9 citations in OpenAlex.
- One-carbon metabolism and cardiovascular disease: Molecular mechanisms, genetic influences, and epigenetic regulation.Biochemistry and biophysics reports · 2026Review
- Association between dietary B vitamins intake and age-specific blood pressure: A cross-sectional study in American adults.PloS one · 2025Article
- Impaired coronary blood flow may be related to elevated homocysteine levels in patients with metabolic syndrome.Wiener klinische Wochenschrift · 2015Article
- Hyperhomocysteinemia as a metabolic disorder parameter is independently associated with the severity of coronary heart disease.Saudi medical journal · 2015Article
- Vitamin status in elderly people in relation to the use of nutritional supplements.The journal of nutrition, health & aging · 2012Article
- The role of VEGF and KDR polymorphisms in moyamoya disease and collateral revascularization.PloS one · 2012Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveHomocysteine is a cardiovascular risk factor, its metabolism is influenced by certain B vitamins and it is associated with endothelial dysfunction probably due to impaired bioavailability of NO caused by homocysteine-induced accumulation of asymmetric dimethylarginine (ADMA), an endogenous inhibitor of NO synthase. On this basis, we investigated the cardiovascular risk factors homocysteine and ADMA in relation to vitamins B(6), B(12) and folate in elderly people.
methodsA total of 102 subjects were recruited and divided into three groups according to age: A (70-74y, n = 48), B (75-79y, n = 35) and C (≥80y, n = 19). Plasma levels of vitamin B(6) were determined with HPLC, vitamin B(12) and folate by RIA. Plasma concentrations of homocysteine were analyzed with HPLC and levels of ADMA were measured by ELISA.
resultsPlasma levels of vitamins B(6), B(12) and folate were found to be adequate in 93, 67 and 55% of participants, respectively. This study showed a significant age-associated decrease in vitamins B(6) (A > B, A > C: p < 0.05), B(12) and folate (A > C: p < 0.05) in parallel to a significant age-related increase in the cardiovascular risk factors homocysteine (A < C, B < C: p < 0.05) and ADMA (A < B: p < 0.05; A < C: p < 0.001). Moreover, homocysteine was significantly negatively (p < 0.01) related to vitamins B(6), B(12) and folate, and significantly positively (p < 0.01) correlated to ADMA.
conclusionsThe significant correlation between homocysteine and ADMA observed in this study may be an important mechanism decreasing NO bioavailability and so causing endothelial dysfunction. Due to the significant relation of vitamins B(6), B(12) and folate to plasma homocysteine, these vitamins may thus indirectly influence endothelial function and cardiovascular risk in elderly people.
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