ArticleRheumatology international2012
Susceptibility to ankylosing spondylitis: evidence for the role of ERAP1, TGFb1 and TLR9 gene polymorphisms.
Article in Rheumatology international, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 3 syntheses or guidelines pooled it, 17 citations in OpenAlex.
- Associations between ERAP1 polymorphisms and susceptibility to ankylosing spondylitis: A meta-analysis of East Asian Population.Medicine · 2018Pooled it
- Bioinformatics analysis of genetic variants of endoplasmic reticulum aminopeptidase 1 in ankylosing spondylitis.Molecular medicine reports · 2017Pooled it
- Associations between ERAP1 polymorphisms and susceptibility to ankylosing spondylitis: a meta-analysis.Clinical rheumatology · 2016Pooled it
- Review
- Lack of Association between Cytokine Genetic Polymorphisms in Takayasu's Arteritis in Mexican Patients.International journal of environmental research and public health · 2019Article
- Ankylosing spondylitis: from cells to genes.International journal of inflammation · 2013Article
- Significant association between insertion/deletion polymorphism of the angiotensin-convertig enzyme gene and ankylosing spondylitis.Molecular vision · 2012Article
- Disease activity in axial spondyloarthritis after discontinuation of TNF inhibitors therapy.ReumatologiaArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Genetic factors are thought to be crucial in the pathogenesis of ankylosing spondylitis (AS). Recent studies have reported that ERAP1, TGBβ1 and TLRs genes are likely to have association with AS in different populations. We carried out this study to determine whether single-nucleotide polymorphisms covering the three genes are associated with AS in a Chinese Han population. Genomic DNA was isolated from the peripheral blood of 328 patients with AS and 627 healthy blood donors from Jinan region as a case-control study. The diagnosis of AS was made according to the modified New York criteria. The ERAP1 rs27044, TGBβ1 rs1800470 and TLR9 rs55704465 were genotyped by a polymerase chain reaction--restriction fragment length polymorphism method. Strong association with AS was observed for marker rs27044, but no significant differences were observed between AS patients and controls in the frequencies of the carriership of the alleles rs55704465 and rs1800470. Our data thus indicate that ERAP1 likely constitutes one of AS-associated loci of susceptibility after HLA in Chinese Han population. On the contrary, TGFB1 and TLR9 variations show no association with the susceptibility of AS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.