ArticleEuropean journal of pediatrics2012
Complications in hospitalized children with acute gastroenteritis caused by rotavirus: a retrospective analysis.
Article in European journal of pediatrics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 36 citations in OpenAlex.
- Neurological complications of rotavirus infection in pediatric patients: a retrospective cohort study.Acta neurologica Belgica · 2026Article
- Hidden Circulation and Socio-Sanitary Vulnerability: Rotavirus A and Human Adenovirus Prevalence in Symptomatic and Asymptomatic Children in Central Brazil Post-COVID-19.Pathogens (Basel, Switzerland) · 2025Article
- Impact of organ dysfunction on outcomes in pediatric hypernatremia: a retrospective observational study.Pediatric nephrology (Berlin, Germany) · 2025Observational
- Electrolyte abnormalities and clinical outcomes in children aged one month to 13 years hospitalized with acute gastroenteritis in two large referral hospitals in Botswana.PLOS global public health · 2025Article
- The disease and economic burden of notified and underestimated Campylobacter enteritis cases and associated sequelae in Germany.PloS one · 2025Article
- Dysnatremia and subsequent sodium level changes following various intravenous treatments in infants with acute gastroenteritis.European journal of pediatrics · 2023Article
- The influence of demographic and meteorological factors on temporal patterns of rotavirus infection in Dhaka, Bangladesh.Proceedings. Biological sciences · 2022Article
- National Consensus for the Management of Acute Gastroenteritis in Jordanian Children: Consensus Recommendations Endorsed by the Jordanian Paediatric Society.International journal of pediatrics · 2022Review
- Clinical Features and Outcomes of Children Admitted to the PICU due to Rotavirus Infection.Turkish archives of pediatrics · 2021Article
- The Utility of Bedside Assessment Tools and Associated Factors to Avoid Antibiotic Overuse in an Urban PICU of a Diarrheal Disease Hospital in Bangladesh.Antibiotics (Basel, Switzerland) · 2021Article
- Acute Infectious Gastroenteritis in Infancy and Childhood.Deutsches Arzteblatt international · 2020Review
- Clinical characteristics and complications of rotavirus gastroenteritis in children in east London: A retrospective case-control study.PloS one · 2018Article
- Long-term outcome of isobutyryl-CoA dehydrogenase deficiency diagnosed following an episode of ketotic hypoglycaemia.Molecular genetics and metabolism reports · 2017Article
- Transient Creatine Kinase Elevation Followed by Hypocomplementemia in a Case of Rotavirus Myositis.Case reports in pediatrics · 2016Article
- Population-based estimate of the burden of acute gastrointestinal illness in Jiangsu province, China, 2010-2011.Epidemiology and infection · 2013Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
unlabelledAcute gastroenteritis (AGE) caused by rotavirus (RV) is a common disease among infants and toddlers, often leading to hospitalization and, in resource-poor countries, to death. However, little is known on specific complications of severe RV-positive (RV+) AGE and on the clinical course in chronically ill children. This was a retrospective analysis of data for children <5 years of age hospitalized due to AGE during six rotavirus seasons in three large German pediatric hospitals. The primary study end point was the incidence and type of complications in RV+ versus RV-negative (RV-) cases. A total of 6,884 episodes of AGE in hospitalized children aged <5 years were included in this analysis. Of the 4,880 stools tested for RV, 2,118 (43.4%) were RV+. Hypernatremia was significantly more common in RV+ AGE (P < 0.001) and was associated with severe disease, need for intensive care treatment, and longer duration of hospitalization. Metabolic disorders, particularly hypoglycemia, were more common in RV+ AGE. In contrast, symptoms such as respiratory infections, neurological, and abdominal symptoms were more common in children with RV- AGE.
conclusionsHypernatremia is a specific complication of RV+ AGE. RV would therefore appear to be the cause of infant toxicosis, the traditional descriptive term for severe dehydration and clinical deterioration following AGE.
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