ArticleJournal of neural transmission (Vienna, Austria : 1996)2012
A 14 bp indel variation in the NCX1 gene modulates the age at onset in late-onset Alzheimer's disease.
Article in Journal of neural transmission (Vienna, Austria : 1996), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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5 citing papers in PubMed, 5 citations in OpenAlex.
- Interactions between calcium intake and polymorphisms in genes essential for calcium reabsorption and risk of colorectal neoplasia in a two-phase study.Molecular carcinogenesis · 2017Article
- Computational approaches to study the effects of small genomic variations.Journal of molecular modeling · 2015Review
- Discriminating between deleterious and neutral non-frameshifting indels based on protein interaction networks and hybrid properties.Molecular genetics and genomics : MGG · 2015Article
- The Subread aligner: fast, accurate and scalable read mapping by seed-and-vote.Nucleic acids research · 2013Article
- Probing the role of the sodium/calcium exchanger in pentylenetetrazole-induced generalized seizures in rats.Brain research bulletin · 2013Article
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Authors and funding
7 authors at 3 institutions in 1 country.
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Abstract
Calcium homeostasis is critical to amyloid beta precursor protein (APP) processing. Na(+)/Ca(2+) exchanger (NCX) proteins play an important role in maintaining intracellular Na(+) and Ca(2+) homeostasis in the brain under physiological and pathological conditions. We sequenced a hyper-variable region in intron 2 of the Na(+)/Ca(2+) exchanger 1 gene (NCX1), and investigated whether insertion/deletion variations in this region are associated with the occurrence for Alzheimer's disease (AD). Examining 413 AD patients and 361 healthy controls, we identified 3 insertion/deletion polymorphisms. No significant differences of the allele and genotype frequencies were observed between the AD cases and the controls for any of the three polymorphisms. However, among the AD patients whose age at onset (AAO) was 65 years or older (n = 299), carriers of a 14 bp insertion showed a lower average AAO (ins/ins and ins/del vs. del/del, 72.49 ± 5.17 vs. 74.28 ± 5.79, p = 0.016). It suggested that this 14 bp insertion/deletion polymorphism might modulate AAO in late-onset AD patients.
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