ArticleBiomedical optics express2011
Multimodal characterization of compositional, structural and functional features of human atherosclerotic plaques.
Article in Biomedical optics express, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 36 citations in OpenAlex.
- A Review of Intravascular Ultrasound-based Multimodal Intravascular Imaging: The Synergistic Approach to Characterizing Vulnerable Plaques.Ultrasonic imaging · 2016Review
- Simultaneous morphological and biochemical endogenous optical imaging of atherosclerosis.European heart journal. Cardiovascular Imaging · 2015Article
- Fluorescence lifetime imaging and intravascular ultrasound: co-registration study using ex vivo human coronaries.IEEE transactions on medical imaging · 2015Article
- Time-resolved fluorescence spectroscopy and ultrasound backscatter microscopy for nondestructive evaluation of vascular grafts.Journal of biomedical optics · 2014Article
- Confocal acoustic radiation force optical coherence elastography using a ring ultrasonic transducer.Applied physics letters · 2014Article
- Ultrasound backscatter microscopy for imaging of oral carcinoma.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2013Article
- Endoscopic fluorescence lifetime imaging for in vivo intraoperative diagnosis of oral carcinoma.Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada · 2013Article
- In vivo validation of a bimodal technique combining time-resolved fluorescence spectroscopy and ultrasonic backscatter microscopy for diagnosis of oral carcinoma.Journal of biomedical optics · 2012Article
- Nondestructive evaluation of tissue engineered articular cartilage using time-resolved fluorescence spectroscopy and ultrasound backscatter microscopy.Tissue engineering. Part C, Methods · 2012Article
- A novel method for fast and robust estimation of fluorescence decay dynamics using constrained least-squares deconvolution with Laguerre expansion.Physics in medicine and biology · 2012Article
- Fluorescence lifetime techniques in medical applications.Annals of biomedical engineering · 2012Review
- Biochemical characterization of atherosclerotic plaques by endogenous multispectral fluorescence lifetime imaging microscopy.Atherosclerosis · 2012Article
- Fluorescence lifetime imaging for the characterization of the biochemical composition of atherosclerotic plaques.Journal of biomedical optics · 2011Article
- Fluorescence Lifetime Spectroscopy and Imaging in Neurosurgery.IEEE journal of selected topics in quantum electronics : a publication of the IEEE Lasers and Electro-optics SocietyArticle
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
Abstract
Detection of atherosclerotic plaque vulnerability has critical clinical implications for avoiding sudden death in patients with high risk of plaque rupture. We report on multimodality imaging of ex-vivo human carotid plaque samples using a system that integrates fluorescence lifetime imaging (FLIM), ultrasonic backscatter microscopy (UBM), and photoacoustic imaging (PAI). Biochemical composition is differentiated with a high temporal resolution and sensitivity at the surface of the plaque by the FLIM subsystem. 3D microanatomy of the whole plaque is reconstructed by the UBM. Functional imaging associated with optical absorption contrast is evaluated from the PAI component. Simultaneous recordings of the optical, ultrasonic, and photoacoustic data present a wealth of complementary information concerning the plaque composition, structure, and function that are related to plaque vulnerability. This approach is expected to improve our ability to study atherosclerotic plaques. The multimodal system presented here can be translated into a catheter based intraluminal system for future clinical studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.