Evidence map›Paper›PMID 21833331›Full record

ArticleFrontiers in microbiology2011

The intestinal microbiota and viral susceptibility.

Julie K Pfeiffer, Justin L Sonnenburg

Abstract read
In one paragraph

Article in Frontiers in microbiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

  1. Article
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  6. Article
  7. Frontiers in immunology · 2020
    Article
  8. Review
  9. Article
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  11. Article
  12. Article
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  19. Review
  20. Human health and disease in a microbial world.Frontiers in microbiology · 2011
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Julie K PfeifferDepartment of Microbiology, University of Texas Southwestern Medical Center Dallas, TX, USA.
Justin L Sonnenburg

Funding

Impact of Diet on Intestinal Microbiota-Host DynamicsR01DK085025 · NIDDK · STANFORD UNIVERSITY · PI JUSTIN L SONNENBURG · 2010 to 2026
$6.4M
The influence of host barriers on viral quasispecies diversity and pathogenesisR01AI074668 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI PFEIFFER, JULIE K · 2008 to 2022
$6.0M
Enteric virus-microbiota interactionsR37AI074668 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI Julie K Pfeiffer · 2023 to 2026
$2.5M
NIAID NIH HHS R01 AI074668NIAID NIH HHS R37 AI074668NIDDK NIH HHS R01 DK085025
6 · The paper itself

Abstract

Many infections start with microbial invasion of mucosal surfaces, which are typically colonized by a community of resident microbes. A growing body of literature demonstrates that the resident microbiota plays a significant role in host susceptibility to pathogens. Recent work has largely focused on the considerable effect that the intestinal microbiota can have upon bacterial pathogenesis. These studies reveal many significant gaps in our knowledge about the mechanisms by which the resident community impacts pathogen invasion and the nature of the ensuing host immune response. It is likely that as viral pathogens become the focus of studies that examine microbiota-host interaction, substantial effects of resident communities exerted via diverse mechanisms will be elucidated. Here we provide a perspective of the exciting emerging field that examines how the intestinal microbiota influences host susceptibility to viruses.

Indexed as

infectionintestinal microbiotamucosal immune systempathogenvirus

Identifiers

PMID21833331
PMCPMC3153051

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.