ArticleFrontiers in neuroscience2011
Two independent networks of interstitial cells of cajal work cooperatively with the enteric nervous system to create colonic motor patterns.
Article in Frontiers in neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
51 citing papers in PubMed, 112 citations in OpenAlex.
- A Biophysical Model of Human Colonic Motor Pattern Generation in Health and Disease.bioRxiv : the preprint server for biology · 2026Article
- Digestive Neurobiology in Autism: From Enteric and Central Nervous System Interactions to Shared Genetic Pathways.International journal of molecular sciences · 2025Review
- Article
- Unique properties of proximal and distal colon reflect distinct motor functions.American journal of physiology. Gastrointestinal and liver physiology · 2025Review
- Exploration of the complex origins of primary constipation.World journal of clinical cases · 2024Review
- Ingesting yeast extract causes excitation of neurogenic and myogenic colonic motor patterns in the rat.Journal of cellular and molecular medicine · 2024Article
- Interstitial Cells of Cajal and Enteric Nervous System in Gastrointestinal and Neurological Pathology, Relation to Oxidative Stress.Current issues in molecular biology · 2023Review
- The enteric nervous system deficits in autism spectrum disorder.Frontiers in neuroscience · 2023Review
- Association Between the Cool Temperature-dependent Suppression of Colonic Peristalsis and Transient Receptor Potential Melastatin 8 Activation in Both a Randomized Clinical Trial and an Animal Model.Journal of neurogastroenterology and motility · 2022Article
- Activation of ENS Circuits in Mouse Colon: Coordination in the Mouse Colonic Motor Complex as a Robust, Distributed Control System.Advances in experimental medicine and biology · 2022Review
- Trans-illumination intestine projection imaging of intestinal motility in mice.Nature communications · 2021Article
- The Role of HAdvances in experimental medicine and biology · 2021Article
- Distinct patterns of myogenic motor activity identified in isolated human distal colon with high-resolution manometry.Neurogastroenterology and motility · 2020Article
- Relationships Between Distention-, Butyrate- and Pellet-Induced Stimulation of Peristalsis in the Mouse Colon.Frontiers in physiology · 2020Article
- Automated Analysis Using a Bayesian Functional Mixed-Effects Model With Gaussian Process Responses for Wavelet Spectra of Spatiotemporal Colonic Manometry Signals.Frontiers in physiology · 2020Article
- Daikenchuto, a traditional Japanese herbal medicine, promotes colonic transit by inducing a propulsive movement pattern.Neurogastroenterology and motility · 2019Article
- First translational consensus on terminology and definitions of colonic motility in animals and humans studied by manometric and other techniques.Nature reviews. Gastroenterology & hepatology · 2019Review
- Alterations in Galanin-Like Immunoreactivity in the Enteric Nervous System of the Porcine Stomach Following Acrylamide Supplementation.International journal of molecular sciences · 2019Article
- Different distributions of interstitial cells of Cajal and platelet-derived growth factor receptor-α positive cells in colonic smooth muscle cell/interstitial cell of Cajal/platelet-derived growth factor receptor-α positive cell syncytium in mice.World journal of gastroenterology · 2018Article
- Opportunities and Challenges for Single-Unit Recordings from Enteric Neurons in Awake Animals.Micromachines · 2018Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Normal motility of the colon is critical for quality of life and efforts to normalize abnormal colon function have had limited success. A better understanding of control systems of colonic motility is therefore essential. We report here a hypothesis with supporting experimental data to explain the origin of rhythmic propulsive colonic motor activity induced by general distention. The theory holds that both networks of interstitial cells of Cajal (ICC), those associated with the submuscular plexus (ICC-SMP) and those associated with the myenteric plexus (ICC-MP), orchestrate propagating contractions as pacemaker cells in concert with the enteric nervous system (ENS). ICC-SMP generate an omnipresent slow wave activity that causes propagating but non-propulsive contractions ("rhythmic propagating ripples") enhancing absorption. The ICC-MP generate stimulus-dependent cyclic depolarizations propagating anally and directing propulsive activity ("rhythmic propulsive motor complexes"). The ENS is not essential for both rhythmic motor patterns since distention and pharmacological means can produce the motor patterns after blocking neural activity, but it supplies the primary stimulus in vivo. Supporting data come from studies on segments of the rat colon, simultaneously measuring motility through spatiotemporal mapping of video recordings, intraluminal pressure, and outflow measurements.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.